Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

Although dietary gluten is the trigger, celiac disease risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine-mapped the MHC association signal to identify additional risk factors independent of the HLA-DQ alleles and observed five novel associ...

Descripción completa

Detalles Bibliográficos
Autores principales: Gutierrez-Achury, Javier, Zhernakova, Alexandra, Pulit, Sara L., Trynka, Gosia, Hunt, Karen A., Romanos, Jihane, Raychaudhuri, Soumya, van Heel, David A., Wijmenga, Cisca, de Bakker, Paul I.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449296/
https://www.ncbi.nlm.nih.gov/pubmed/25894500
http://dx.doi.org/10.1038/ng.3268
_version_ 1782373835890229248
author Gutierrez-Achury, Javier
Zhernakova, Alexandra
Pulit, Sara L.
Trynka, Gosia
Hunt, Karen A.
Romanos, Jihane
Raychaudhuri, Soumya
van Heel, David A.
Wijmenga, Cisca
de Bakker, Paul I.W.
author_facet Gutierrez-Achury, Javier
Zhernakova, Alexandra
Pulit, Sara L.
Trynka, Gosia
Hunt, Karen A.
Romanos, Jihane
Raychaudhuri, Soumya
van Heel, David A.
Wijmenga, Cisca
de Bakker, Paul I.W.
author_sort Gutierrez-Achury, Javier
collection PubMed
description Although dietary gluten is the trigger, celiac disease risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine-mapped the MHC association signal to identify additional risk factors independent of the HLA-DQ alleles and observed five novel associations that account for 18% of the genetic risk. Together with the 57 known non-MHC loci, genetic variation can now explain up to 48% of celiac disease heritability.
format Online
Article
Text
id pubmed-4449296
institution National Center for Biotechnology Information
language English
publishDate 2015
record_format MEDLINE/PubMed
spelling pubmed-44492962015-12-01 Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease Gutierrez-Achury, Javier Zhernakova, Alexandra Pulit, Sara L. Trynka, Gosia Hunt, Karen A. Romanos, Jihane Raychaudhuri, Soumya van Heel, David A. Wijmenga, Cisca de Bakker, Paul I.W. Nat Genet Article Although dietary gluten is the trigger, celiac disease risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine-mapped the MHC association signal to identify additional risk factors independent of the HLA-DQ alleles and observed five novel associations that account for 18% of the genetic risk. Together with the 57 known non-MHC loci, genetic variation can now explain up to 48% of celiac disease heritability. 2015-04-20 2015-06 /pmc/articles/PMC4449296/ /pubmed/25894500 http://dx.doi.org/10.1038/ng.3268 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Gutierrez-Achury, Javier
Zhernakova, Alexandra
Pulit, Sara L.
Trynka, Gosia
Hunt, Karen A.
Romanos, Jihane
Raychaudhuri, Soumya
van Heel, David A.
Wijmenga, Cisca
de Bakker, Paul I.W.
Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease
title Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease
title_full Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease
title_fullStr Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease
title_full_unstemmed Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease
title_short Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease
title_sort fine-mapping in the mhc region accounts for 18% additional genetic risk for celiac disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449296/
https://www.ncbi.nlm.nih.gov/pubmed/25894500
http://dx.doi.org/10.1038/ng.3268
work_keys_str_mv AT gutierrezachuryjavier finemappinginthemhcregionaccountsfor18additionalgeneticriskforceliacdisease
AT zhernakovaalexandra finemappinginthemhcregionaccountsfor18additionalgeneticriskforceliacdisease
AT pulitsaral finemappinginthemhcregionaccountsfor18additionalgeneticriskforceliacdisease
AT trynkagosia finemappinginthemhcregionaccountsfor18additionalgeneticriskforceliacdisease
AT huntkarena finemappinginthemhcregionaccountsfor18additionalgeneticriskforceliacdisease
AT romanosjihane finemappinginthemhcregionaccountsfor18additionalgeneticriskforceliacdisease
AT raychaudhurisoumya finemappinginthemhcregionaccountsfor18additionalgeneticriskforceliacdisease
AT vanheeldavida finemappinginthemhcregionaccountsfor18additionalgeneticriskforceliacdisease
AT wijmengacisca finemappinginthemhcregionaccountsfor18additionalgeneticriskforceliacdisease
AT debakkerpauliw finemappinginthemhcregionaccountsfor18additionalgeneticriskforceliacdisease

Ejemplares similares