Cargando…

Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

Although dietary gluten is the trigger, celiac disease risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine-mapped the MHC association signal to identify additional risk factors independent of the HLA-DQ alleles and observed five novel associ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gutierrez-Achury, Javier, Zhernakova, Alexandra, Pulit, Sara L., Trynka, Gosia, Hunt, Karen A., Romanos, Jihane, Raychaudhuri, Soumya, van Heel, David A., Wijmenga, Cisca, de Bakker, Paul I.W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449296/ https://www.ncbi.nlm.nih.gov/pubmed/25894500 http://dx.doi.org/10.1038/ng.3268

Ejemplares similares

Evaluation of European coeliac disease risk variants in a north Indian population
por: Senapati, Sabyasachi, et al.
Publicado: (2015)

Contrasting the Genetic Background of Type 1 Diabetes and Celiac Disease Autoimmunity
por: Gutierrez-Achury, Javier, et al.
Publicado: (2015)

Effective Detection of Human Leukocyte Antigen Risk Alleles in Celiac Disease Using Tag Single Nucleotide Polymorphisms
por: Monsuur, Alienke J., et al.
Publicado: (2008)

Correction: Effective Detection of Human Leukocyte Antigen Risk Alleles in Celiac Disease Using Tag Single Nucleotide Polymorphisms
por: Monsuur, Alienke J., et al.
Publicado: (2009)

Potential Celiac Patients: A Model of Celiac Disease Pathogenesis
por: Sperandeo, Maria Pia, et al.
Publicado: (2011)

The MHC locus and genetic susceptibility to autoimmune and infectious diseases
por: Matzaraki, Vasiliki, et al.
Publicado: (2017)

Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant
por: Almeida, Rodrigo, et al.
Publicado: (2014)

No Evidence in a Large UK Collection for Celiac Disease Risk Variants Reported by a Spanish Study
por: Hunt, Karen A., et al.
Publicado: (2008)

Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants
por: Romanos, Jihane, et al.
Publicado: (2014)

Complex nature of SNP genotype effects on gene expression in primary human leucocytes
por: Heap, Graham A, et al.
Publicado: (2009)

The influence of a short-term gluten-free diet on the human gut microbiome
por: Bonder, Marc Jan, et al.
Publicado: (2016)

Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci
por: Zhernakova, Alexandra, et al.
Publicado: (2011)

A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease
por: Festen, Eleonora A. M., et al.
Publicado: (2011)

Tissue-Specific Enrichment of Lymphoma Risk Loci in Regulatory Elements
por: Hayes, James E., et al.
Publicado: (2015)

Celiac disease-on-chip: Modeling a multifactorial disease in vitro
por: Moerkens, Renée, et al.
Publicado: (2019)

From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseases
por: Kumar, Vinod, et al.
Publicado: (2012)

Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations
por: Márquez, Ana, et al.
Publicado: (2018)

Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases
por: Lenz, Tobias L., et al.
Publicado: (2015)

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
por: Trynka, Gosia, et al.
Publicado: (2011)

Multiple common variants for celiac disease influencing immune gene expression
por: Dubois, Patrick CA, et al.
Publicado: (2010)

Studying the gut virome in the metagenomic era: challenges and perspectives
por: Garmaeva, Sanzhima, et al.
Publicado: (2019)

Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci
por: Trynka, Gosia, et al.
Publicado: (2015)

The Tip of the “Celiac Iceberg” in China: A Systematic Review and Meta-Analysis
por: Yuan, Juanli, et al.
Publicado: (2013)

Functional studies of GWAS variants are gaining momentum
por: Lichou, Florence, et al.
Publicado: (2020)

Effects of Non-HLA Gene Polymorphisms on Development of Islet Autoimmunity and Type 1 Diabetes in a Population With High-Risk HLA-DR,DQ Genotypes
por: Steck, Andrea K., et al.
Publicado: (2012)

The SPINK gene family and celiac disease susceptibility
por: Wapenaar, Martin C., et al.
Publicado: (2007)

From GWAS to Function: Using Functional Genomics to Identify the Mechanisms Underlying Complex Diseases
por: Cano-Gamez, Eddie, et al.
Publicado: (2020)

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis
por: Raychaudhuri, Soumya, et al.
Publicado: (2012)

Variants in Neuropeptide Y Receptor 1 and 5 Are Associated with Nutrient-Specific Food Intake and Are Under Recent Selection in Europeans
por: Elbers, Clara C., et al.
Publicado: (2009)

Interactions within the MHC contribute to the genetic architecture of celiac disease
por: Goudey, Benjamin, et al.
Publicado: (2017)

Immunogenomic approaches to understand the function of immune disease variants
por: Glinos, Dafni A., et al.
Publicado: (2017)

Circulating miRNAs as Potential Biomarkers for Celiac Disease Development
por: Tan, Ineke L., et al.
Publicado: (2021)

Expressing the Differences between Crohn Disease and Ulcerative Colitis
por: Wijmenga, Cisca
Publicado: (2005)

Classical HLA-DRB1 and DPB1 Alleles Account for HLA Associations with Primary Biliary Cirrhosis
por: Invernizzi, Pietro, et al.
Publicado: (2012)

High density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
por: Eyre, Steve, et al.
Publicado: (2012)

A Combined mRNA- and miRNA-Sequencing Approach Reveals miRNAs as Potential Regulators of the Small Intestinal Transcriptome in Celiac Disease
por: Tan, Ineke Luise, et al.
Publicado: (2021)

Context-specific effects of genetic variants associated with autoimmune disease
por: Jonkers, Iris H., et al.
Publicado: (2017)

Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens
por: Jia, Xiaoming, et al.
Publicado: (2013)

Pharmacomicrobiomics: a novel route towards personalized medicine?
por: Doestzada, Marwah, et al.
Publicado: (2018)

Frequency and characterization of celiac ganglia diagnosed on fine-needle aspiration
por: ElGabry, Ehab A., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_3rj5sc2fhu56fp16qkcgifpdg2