NALP3 inflammasome up-regulation and CASP1 cleavage of the glucocorticoid receptor causes glucocorticoid resistance in leukemia cells

Glucocorticoids are universally used in the treatment of acute lymphoblastic leukemia (ALL), and leukemia cell resistant to glucocorticoids confers a poor prognosis. To elucidate mechanisms of glucocorticoid resistance, we determined the sensitivity to prednisolone of primary leukemia cells from 444...

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Detalles Bibliográficos
Autores principales: Paugh, Steven W., Bonten, Erik J., Savic, Daniel, Ramsey, Laura B., Thierfelder, William E., Gurung, Prajwal, Malireddi, R. K. Subbarao, Actis, Marcelo, Mayasundari, Anand, Min, Jaeki, Coss, David R., Laudermilk, Lucas T., Panetta, John C., McCorkle, J. Robert, Fan, Yiping, Crews, Kristine R., Stocco, Gabriele, Wilkinson, Mark R., Ferreira, Antonio M., Cheng, Cheng, Yang, Wenjian, Karol, Seth E., Fernandez, Christian A., Diouf, Barthelemy, Smith, Colton, Hicks, J. Kevin, Zanut, Alessandra, Giordanengo, Audrey, Crona, Daniel, Bianchi, Joy J., Holmfeldt, Linda, Mullighan, Charles G., den Boer, Monique L., Pieters, Rob, Jeha, Sima, Dunwell, Thomas L., Latif, Farida, Bhojwani, Deepa, Carroll, William L., Pui, Ching-Hon, Myers, Richard M., Guy, R. Kiplin, Kanneganti, Thirumala-Devi, Relling, Mary V., Evans, William E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449308/
https://www.ncbi.nlm.nih.gov/pubmed/25938942
http://dx.doi.org/10.1038/ng.3283

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