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Effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks in migraine patients with aura: A double-blind randomized clinical trial study in Iran

Background: Migraine is a chronic disease that affects nearly 6% of men and 18% of women worldwide. There are various drugs, which can successfully decrease migraine symptoms and frequency of migraine attacks, but these drugs usually are expensive. Hence, this study aimed to assess the effects of py...

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Autores principales: Sadeghi, Omid, Nasiri, Morteza, Maghsoudi, Zahra, Pahlavani, Naseh, Rezaie, Masoud, Askari, Gholamreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449397/
https://www.ncbi.nlm.nih.gov/pubmed/26056551
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author Sadeghi, Omid
Nasiri, Morteza
Maghsoudi, Zahra
Pahlavani, Naseh
Rezaie, Masoud
Askari, Gholamreza
author_facet Sadeghi, Omid
Nasiri, Morteza
Maghsoudi, Zahra
Pahlavani, Naseh
Rezaie, Masoud
Askari, Gholamreza
author_sort Sadeghi, Omid
collection PubMed
description Background: Migraine is a chronic disease that affects nearly 6% of men and 18% of women worldwide. There are various drugs, which can successfully decrease migraine symptoms and frequency of migraine attacks, but these drugs usually are expensive. Hence, this study aimed to assess the effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks as well as headache diary results (HDR). Methods: This double-blind randomized clinical trial study was conducted on 66 patients with migraine with aura (MA) in Khorshid and Emam Mosa Sadr clinics of Isfahan University of Medical Sciences, Iran, in 2013. Patients were randomly allocated to receive either pyridoxine supplements (80 mg pyridoxine per day) or placebo. Severity, frequency and duration of migraine attacks and HDR were measured at baseline and at the end of the study. Results: Mean age of patients was 34.24 ± 9.44 years old. Pyridoxine supplementation led to a significant decrease in headache severity (−2.20 ± 1.70 compared with −1 ± 1.50; P = 0.007), attacks duration (−8.30 ± 12.60 compared with −1.70 ± 9.60; P = 0.030) and HDR (−89.70 ± 134.60 compared with −6.10 ± 155.50; P = 0.040) compared with placebo, but was not effective on the frequency of migraine attacks (−2.30 ± 4 compared with −1.20 ± 7.80; P = 0.510). Conclusion: Pyridoxine supplementation in patients with MA was effective on headache severity, attacks duration and HDR, but did not affect the frequency of migraine attacks.
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spelling pubmed-44493972015-06-08 Effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks in migraine patients with aura: A double-blind randomized clinical trial study in Iran Sadeghi, Omid Nasiri, Morteza Maghsoudi, Zahra Pahlavani, Naseh Rezaie, Masoud Askari, Gholamreza Iran J Neurol Original Article Background: Migraine is a chronic disease that affects nearly 6% of men and 18% of women worldwide. There are various drugs, which can successfully decrease migraine symptoms and frequency of migraine attacks, but these drugs usually are expensive. Hence, this study aimed to assess the effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks as well as headache diary results (HDR). Methods: This double-blind randomized clinical trial study was conducted on 66 patients with migraine with aura (MA) in Khorshid and Emam Mosa Sadr clinics of Isfahan University of Medical Sciences, Iran, in 2013. Patients were randomly allocated to receive either pyridoxine supplements (80 mg pyridoxine per day) or placebo. Severity, frequency and duration of migraine attacks and HDR were measured at baseline and at the end of the study. Results: Mean age of patients was 34.24 ± 9.44 years old. Pyridoxine supplementation led to a significant decrease in headache severity (−2.20 ± 1.70 compared with −1 ± 1.50; P = 0.007), attacks duration (−8.30 ± 12.60 compared with −1.70 ± 9.60; P = 0.030) and HDR (−89.70 ± 134.60 compared with −6.10 ± 155.50; P = 0.040) compared with placebo, but was not effective on the frequency of migraine attacks (−2.30 ± 4 compared with −1.20 ± 7.80; P = 0.510). Conclusion: Pyridoxine supplementation in patients with MA was effective on headache severity, attacks duration and HDR, but did not affect the frequency of migraine attacks. Tehran University of Medical Sciences 2015-04-04 /pmc/articles/PMC4449397/ /pubmed/26056551 Text en Copyright © 2015 Iranian Neurological Association, and Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sadeghi, Omid
Nasiri, Morteza
Maghsoudi, Zahra
Pahlavani, Naseh
Rezaie, Masoud
Askari, Gholamreza
Effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks in migraine patients with aura: A double-blind randomized clinical trial study in Iran
title Effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks in migraine patients with aura: A double-blind randomized clinical trial study in Iran
title_full Effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks in migraine patients with aura: A double-blind randomized clinical trial study in Iran
title_fullStr Effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks in migraine patients with aura: A double-blind randomized clinical trial study in Iran
title_full_unstemmed Effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks in migraine patients with aura: A double-blind randomized clinical trial study in Iran
title_short Effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks in migraine patients with aura: A double-blind randomized clinical trial study in Iran
title_sort effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks in migraine patients with aura: a double-blind randomized clinical trial study in iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449397/
https://www.ncbi.nlm.nih.gov/pubmed/26056551
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