Cancer Risk Assessment in Welder’s Under Different Exposure Scenarios

BACKGROUND: Welders exposure to nickel and hexavalent chromium in welding fumes is associated with increase of cancer risk in welders. In this study we calculated cancer risk due to exposure to these compounds in welders. METHODS: The role of exposure parameters in welders on derived incremental lif...

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Autores principales: BARKHORDARI, Abolfazl, ZARE SAKHVIDI, Mohammad Javad, ZARE SAKHVIDI, Fariba, HALVANI, Gholamhossein, FIROOZICHAHAK, Ali, SHIRALI, GholamAbbas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449415/
https://www.ncbi.nlm.nih.gov/pubmed/26060768
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author BARKHORDARI, Abolfazl
ZARE SAKHVIDI, Mohammad Javad
ZARE SAKHVIDI, Fariba
HALVANI, Gholamhossein
FIROOZICHAHAK, Ali
SHIRALI, GholamAbbas
author_facet BARKHORDARI, Abolfazl
ZARE SAKHVIDI, Mohammad Javad
ZARE SAKHVIDI, Fariba
HALVANI, Gholamhossein
FIROOZICHAHAK, Ali
SHIRALI, GholamAbbas
author_sort BARKHORDARI, Abolfazl
collection PubMed
description BACKGROUND: Welders exposure to nickel and hexavalent chromium in welding fumes is associated with increase of cancer risk in welders. In this study we calculated cancer risk due to exposure to these compounds in welders. METHODS: The role of exposure parameters in welders on derived incremental lifetime cancer risk were determined by stochastic modeling of cancer risk. Input parameters were determined by field investigation in Iranian welders in 2013 and literature review. RESULTS: The 90% upper band cancer risk due to hexavalent chromium and nickel exposure was in the range of 6.03E-03 to 2.12E-02 and 7.18E-03 to 2.61E-02 respectively. Scenario analysis showed that asthmatic and project welders are significantly at higher cancer risk in comparison with other welders (P<0.05). Shift duration was responsible for 37% and 33% of variances for hexavalent chromium and nickel respectively. CONCLUSIONS: Welders are at high and unacceptable risk of cancer. Control measures according to scenario analysis findings are advisable.
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spelling pubmed-44494152015-06-09 Cancer Risk Assessment in Welder’s Under Different Exposure Scenarios BARKHORDARI, Abolfazl ZARE SAKHVIDI, Mohammad Javad ZARE SAKHVIDI, Fariba HALVANI, Gholamhossein FIROOZICHAHAK, Ali SHIRALI, GholamAbbas Iran J Public Health Original Article BACKGROUND: Welders exposure to nickel and hexavalent chromium in welding fumes is associated with increase of cancer risk in welders. In this study we calculated cancer risk due to exposure to these compounds in welders. METHODS: The role of exposure parameters in welders on derived incremental lifetime cancer risk were determined by stochastic modeling of cancer risk. Input parameters were determined by field investigation in Iranian welders in 2013 and literature review. RESULTS: The 90% upper band cancer risk due to hexavalent chromium and nickel exposure was in the range of 6.03E-03 to 2.12E-02 and 7.18E-03 to 2.61E-02 respectively. Scenario analysis showed that asthmatic and project welders are significantly at higher cancer risk in comparison with other welders (P<0.05). Shift duration was responsible for 37% and 33% of variances for hexavalent chromium and nickel respectively. CONCLUSIONS: Welders are at high and unacceptable risk of cancer. Control measures according to scenario analysis findings are advisable. Tehran University of Medical Sciences 2014-05 /pmc/articles/PMC4449415/ /pubmed/26060768 Text en Copyright © Iranian Public Health Association & Tehran University of Medical Sciences This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
BARKHORDARI, Abolfazl
ZARE SAKHVIDI, Mohammad Javad
ZARE SAKHVIDI, Fariba
HALVANI, Gholamhossein
FIROOZICHAHAK, Ali
SHIRALI, GholamAbbas
Cancer Risk Assessment in Welder’s Under Different Exposure Scenarios
title Cancer Risk Assessment in Welder’s Under Different Exposure Scenarios
title_full Cancer Risk Assessment in Welder’s Under Different Exposure Scenarios
title_fullStr Cancer Risk Assessment in Welder’s Under Different Exposure Scenarios
title_full_unstemmed Cancer Risk Assessment in Welder’s Under Different Exposure Scenarios
title_short Cancer Risk Assessment in Welder’s Under Different Exposure Scenarios
title_sort cancer risk assessment in welder’s under different exposure scenarios
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449415/
https://www.ncbi.nlm.nih.gov/pubmed/26060768
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