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Increased circulating macrophage migration inhibitory factor levels are associated with coronary artery disease

BACKGROUND: To evaluate the macrophage migration inhibitory factor and E-selectin levels in patients with acute coronary syndrome. MATERIALS/METHODS: We examined the plasma migration inhibitory factor and E-selectin levels in 87 patients who presented with chest pain at our hospital. The patients we...

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Autores principales: Yüksel, Arif, Bilgir, Ferda, Bilgir, Oktay, Calan, Mehmet, Bozkaya, Giray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculdade de Medicina / USP 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449471/
https://www.ncbi.nlm.nih.gov/pubmed/26017646
http://dx.doi.org/10.6061/clinics/2015(03)03
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author Yüksel, Arif
Bilgir, Ferda
Bilgir, Oktay
Calan, Mehmet
Bozkaya, Giray
author_facet Yüksel, Arif
Bilgir, Ferda
Bilgir, Oktay
Calan, Mehmet
Bozkaya, Giray
author_sort Yüksel, Arif
collection PubMed
description BACKGROUND: To evaluate the macrophage migration inhibitory factor and E-selectin levels in patients with acute coronary syndrome. MATERIALS/METHODS: We examined the plasma migration inhibitory factor and E-selectin levels in 87 patients who presented with chest pain at our hospital. The patients were classified into two groups according to their cardiac status. Sixty-five patients had acute myocardial infarction, and 22 patients had non-cardiac chest pain (non-coronary disease). We designated the latter group of patients as the control group. The patients who presented with acute myocardial infarction were further divided into two subgroups: ST-elevated myocardial infarction (n = 30) and non-ST elevated myocardial infarction (n = 35). RESULTS: We found higher plasma migration inhibitory factor levels in both acute myocardial infarction subgroups than in the control group. However, the E-selectin levels were similar between the acute myocardial infarction and control patients. In addition, we did not find a significant difference in the plasma migration inhibitory factor levels between the ST elevated myocardial infarction and NST-elevated myocardial infarction subgroups. DISCUSSION: The circulating concentrations of migration inhibitory factor were significantly increased in acute myocardial infarction patients, whereas the soluble E-selectin levels were similar between acute myocardial infarction patients and control subjects. Our results suggest that migration inhibitory factor may play a role in the atherosclerotic process.
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spelling pubmed-44494712015-07-08 Increased circulating macrophage migration inhibitory factor levels are associated with coronary artery disease Yüksel, Arif Bilgir, Ferda Bilgir, Oktay Calan, Mehmet Bozkaya, Giray Clinics (Sao Paulo) Clinical Science BACKGROUND: To evaluate the macrophage migration inhibitory factor and E-selectin levels in patients with acute coronary syndrome. MATERIALS/METHODS: We examined the plasma migration inhibitory factor and E-selectin levels in 87 patients who presented with chest pain at our hospital. The patients were classified into two groups according to their cardiac status. Sixty-five patients had acute myocardial infarction, and 22 patients had non-cardiac chest pain (non-coronary disease). We designated the latter group of patients as the control group. The patients who presented with acute myocardial infarction were further divided into two subgroups: ST-elevated myocardial infarction (n = 30) and non-ST elevated myocardial infarction (n = 35). RESULTS: We found higher plasma migration inhibitory factor levels in both acute myocardial infarction subgroups than in the control group. However, the E-selectin levels were similar between the acute myocardial infarction and control patients. In addition, we did not find a significant difference in the plasma migration inhibitory factor levels between the ST elevated myocardial infarction and NST-elevated myocardial infarction subgroups. DISCUSSION: The circulating concentrations of migration inhibitory factor were significantly increased in acute myocardial infarction patients, whereas the soluble E-selectin levels were similar between acute myocardial infarction patients and control subjects. Our results suggest that migration inhibitory factor may play a role in the atherosclerotic process. Faculdade de Medicina / USP 2015-03 2015-03 /pmc/articles/PMC4449471/ /pubmed/26017646 http://dx.doi.org/10.6061/clinics/2015(03)03 Text en Copyright © 2015 Hospital das Clínicas da FMUSP http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Science
Yüksel, Arif
Bilgir, Ferda
Bilgir, Oktay
Calan, Mehmet
Bozkaya, Giray
Increased circulating macrophage migration inhibitory factor levels are associated with coronary artery disease
title Increased circulating macrophage migration inhibitory factor levels are associated with coronary artery disease
title_full Increased circulating macrophage migration inhibitory factor levels are associated with coronary artery disease
title_fullStr Increased circulating macrophage migration inhibitory factor levels are associated with coronary artery disease
title_full_unstemmed Increased circulating macrophage migration inhibitory factor levels are associated with coronary artery disease
title_short Increased circulating macrophage migration inhibitory factor levels are associated with coronary artery disease
title_sort increased circulating macrophage migration inhibitory factor levels are associated with coronary artery disease
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449471/
https://www.ncbi.nlm.nih.gov/pubmed/26017646
http://dx.doi.org/10.6061/clinics/2015(03)03
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