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Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus
OBJECTIVES: To determine the serum interleukin-17 (IL-17) levels in childhood-onset systemic lupus erythematosus patients and to evaluate the association between IL-17 and clinical manifestations, disease activity, laboratory findings and treatment. METHODS: We included 67 consecutive childhood-onse...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449477/ https://www.ncbi.nlm.nih.gov/pubmed/26039945 http://dx.doi.org/10.6061/clinics/2015(05)01 |
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author | de Oliveira Peliçari, Karina Postal, Mariana Sinicato, Nailú Angelica Peres, Fernando Augusto Fernandes, Paula Teixeira Marini, Roberto Costallat, Lilian Tereza Lavras Appenzeller, Simone |
author_facet | de Oliveira Peliçari, Karina Postal, Mariana Sinicato, Nailú Angelica Peres, Fernando Augusto Fernandes, Paula Teixeira Marini, Roberto Costallat, Lilian Tereza Lavras Appenzeller, Simone |
author_sort | de Oliveira Peliçari, Karina |
collection | PubMed |
description | OBJECTIVES: To determine the serum interleukin-17 (IL-17) levels in childhood-onset systemic lupus erythematosus patients and to evaluate the association between IL-17 and clinical manifestations, disease activity, laboratory findings and treatment. METHODS: We included 67 consecutive childhood-onset systemic lupus erythematosus patients [61 women; median age 18 years (range 11-31)], 55 first-degree relatives [50 women; median age 40 years (range 29-52)] and 47 age- and sex-matched healthy controls [42 women; median age 19 years (range 6-30)]. The childhood-onset systemic lupus erythematosus patients were assessed for clinical and laboratory systemic lupus erythematosus manifestations, disease activity [Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)], cumulative damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index] and current drug use. Serum IL-17 levels were measured by an enzyme-linked immunosorbent assay using commercial kits. RESULTS: The median serum IL-17 level was 36.3 (range 17.36-105.92) pg/mL in childhood-onset systemic lupus erythematosus patients and 29.47 (15.16-62.17) pg/mL in healthy controls (p=0.009). We observed an association between serum IL-17 levels and active nephritis (p=0.01) and migraines (p=0.03). Serum IL-17 levels were not associated with disease activity (p=0.32), cumulative damage (p=0.34), or medication use (p=0.63). CONCLUSION: IL-17 is increased in childhood-onset systemic lupus erythematosus and may play a role in the pathogenesis of neuropsychiatric and renal manifestations. Longitudinal studies are necessary to determine the role of IL-17 in childhood-onset systemic lupus erythematosus. |
format | Online Article Text |
id | pubmed-4449477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-44494772015-06-26 Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus de Oliveira Peliçari, Karina Postal, Mariana Sinicato, Nailú Angelica Peres, Fernando Augusto Fernandes, Paula Teixeira Marini, Roberto Costallat, Lilian Tereza Lavras Appenzeller, Simone Clinics (Sao Paulo) Clinical Science OBJECTIVES: To determine the serum interleukin-17 (IL-17) levels in childhood-onset systemic lupus erythematosus patients and to evaluate the association between IL-17 and clinical manifestations, disease activity, laboratory findings and treatment. METHODS: We included 67 consecutive childhood-onset systemic lupus erythematosus patients [61 women; median age 18 years (range 11-31)], 55 first-degree relatives [50 women; median age 40 years (range 29-52)] and 47 age- and sex-matched healthy controls [42 women; median age 19 years (range 6-30)]. The childhood-onset systemic lupus erythematosus patients were assessed for clinical and laboratory systemic lupus erythematosus manifestations, disease activity [Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)], cumulative damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index] and current drug use. Serum IL-17 levels were measured by an enzyme-linked immunosorbent assay using commercial kits. RESULTS: The median serum IL-17 level was 36.3 (range 17.36-105.92) pg/mL in childhood-onset systemic lupus erythematosus patients and 29.47 (15.16-62.17) pg/mL in healthy controls (p=0.009). We observed an association between serum IL-17 levels and active nephritis (p=0.01) and migraines (p=0.03). Serum IL-17 levels were not associated with disease activity (p=0.32), cumulative damage (p=0.34), or medication use (p=0.63). CONCLUSION: IL-17 is increased in childhood-onset systemic lupus erythematosus and may play a role in the pathogenesis of neuropsychiatric and renal manifestations. Longitudinal studies are necessary to determine the role of IL-17 in childhood-onset systemic lupus erythematosus. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2015-05 2015-05 /pmc/articles/PMC4449477/ /pubmed/26039945 http://dx.doi.org/10.6061/clinics/2015(05)01 Text en Copyright © 2015 Clinics http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Science de Oliveira Peliçari, Karina Postal, Mariana Sinicato, Nailú Angelica Peres, Fernando Augusto Fernandes, Paula Teixeira Marini, Roberto Costallat, Lilian Tereza Lavras Appenzeller, Simone Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus |
title | Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus |
title_full | Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus |
title_fullStr | Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus |
title_full_unstemmed | Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus |
title_short | Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus |
title_sort | serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449477/ https://www.ncbi.nlm.nih.gov/pubmed/26039945 http://dx.doi.org/10.6061/clinics/2015(05)01 |
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