Cargando…

Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus

OBJECTIVES: To determine the serum interleukin-17 (IL-17) levels in childhood-onset systemic lupus erythematosus patients and to evaluate the association between IL-17 and clinical manifestations, disease activity, laboratory findings and treatment. METHODS: We included 67 consecutive childhood-onse...

Descripción completa

Detalles Bibliográficos
Autores principales: de Oliveira Peliçari, Karina, Postal, Mariana, Sinicato, Nailú Angelica, Peres, Fernando Augusto, Fernandes, Paula Teixeira, Marini, Roberto, Costallat, Lilian Tereza Lavras, Appenzeller, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449477/
https://www.ncbi.nlm.nih.gov/pubmed/26039945
http://dx.doi.org/10.6061/clinics/2015(05)01
_version_ 1782373856914178048
author de Oliveira Peliçari, Karina
Postal, Mariana
Sinicato, Nailú Angelica
Peres, Fernando Augusto
Fernandes, Paula Teixeira
Marini, Roberto
Costallat, Lilian Tereza Lavras
Appenzeller, Simone
author_facet de Oliveira Peliçari, Karina
Postal, Mariana
Sinicato, Nailú Angelica
Peres, Fernando Augusto
Fernandes, Paula Teixeira
Marini, Roberto
Costallat, Lilian Tereza Lavras
Appenzeller, Simone
author_sort de Oliveira Peliçari, Karina
collection PubMed
description OBJECTIVES: To determine the serum interleukin-17 (IL-17) levels in childhood-onset systemic lupus erythematosus patients and to evaluate the association between IL-17 and clinical manifestations, disease activity, laboratory findings and treatment. METHODS: We included 67 consecutive childhood-onset systemic lupus erythematosus patients [61 women; median age 18 years (range 11-31)], 55 first-degree relatives [50 women; median age 40 years (range 29-52)] and 47 age- and sex-matched healthy controls [42 women; median age 19 years (range 6-30)]. The childhood-onset systemic lupus erythematosus patients were assessed for clinical and laboratory systemic lupus erythematosus manifestations, disease activity [Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)], cumulative damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index] and current drug use. Serum IL-17 levels were measured by an enzyme-linked immunosorbent assay using commercial kits. RESULTS: The median serum IL-17 level was 36.3 (range 17.36-105.92) pg/mL in childhood-onset systemic lupus erythematosus patients and 29.47 (15.16-62.17) pg/mL in healthy controls (p=0.009). We observed an association between serum IL-17 levels and active nephritis (p=0.01) and migraines (p=0.03). Serum IL-17 levels were not associated with disease activity (p=0.32), cumulative damage (p=0.34), or medication use (p=0.63). CONCLUSION: IL-17 is increased in childhood-onset systemic lupus erythematosus and may play a role in the pathogenesis of neuropsychiatric and renal manifestations. Longitudinal studies are necessary to determine the role of IL-17 in childhood-onset systemic lupus erythematosus.
format Online
Article
Text
id pubmed-4449477
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
record_format MEDLINE/PubMed
spelling pubmed-44494772015-06-26 Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus de Oliveira Peliçari, Karina Postal, Mariana Sinicato, Nailú Angelica Peres, Fernando Augusto Fernandes, Paula Teixeira Marini, Roberto Costallat, Lilian Tereza Lavras Appenzeller, Simone Clinics (Sao Paulo) Clinical Science OBJECTIVES: To determine the serum interleukin-17 (IL-17) levels in childhood-onset systemic lupus erythematosus patients and to evaluate the association between IL-17 and clinical manifestations, disease activity, laboratory findings and treatment. METHODS: We included 67 consecutive childhood-onset systemic lupus erythematosus patients [61 women; median age 18 years (range 11-31)], 55 first-degree relatives [50 women; median age 40 years (range 29-52)] and 47 age- and sex-matched healthy controls [42 women; median age 19 years (range 6-30)]. The childhood-onset systemic lupus erythematosus patients were assessed for clinical and laboratory systemic lupus erythematosus manifestations, disease activity [Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)], cumulative damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index] and current drug use. Serum IL-17 levels were measured by an enzyme-linked immunosorbent assay using commercial kits. RESULTS: The median serum IL-17 level was 36.3 (range 17.36-105.92) pg/mL in childhood-onset systemic lupus erythematosus patients and 29.47 (15.16-62.17) pg/mL in healthy controls (p=0.009). We observed an association between serum IL-17 levels and active nephritis (p=0.01) and migraines (p=0.03). Serum IL-17 levels were not associated with disease activity (p=0.32), cumulative damage (p=0.34), or medication use (p=0.63). CONCLUSION: IL-17 is increased in childhood-onset systemic lupus erythematosus and may play a role in the pathogenesis of neuropsychiatric and renal manifestations. Longitudinal studies are necessary to determine the role of IL-17 in childhood-onset systemic lupus erythematosus. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2015-05 2015-05 /pmc/articles/PMC4449477/ /pubmed/26039945 http://dx.doi.org/10.6061/clinics/2015(05)01 Text en Copyright © 2015 Clinics http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Science
de Oliveira Peliçari, Karina
Postal, Mariana
Sinicato, Nailú Angelica
Peres, Fernando Augusto
Fernandes, Paula Teixeira
Marini, Roberto
Costallat, Lilian Tereza Lavras
Appenzeller, Simone
Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus
title Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus
title_full Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus
title_fullStr Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus
title_full_unstemmed Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus
title_short Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus
title_sort serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449477/
https://www.ncbi.nlm.nih.gov/pubmed/26039945
http://dx.doi.org/10.6061/clinics/2015(05)01
work_keys_str_mv AT deoliveirapelicarikarina seruminterleukin17levelsareassociatedwithnephritisinchildhoodonsetsystemiclupuserythematosus
AT postalmariana seruminterleukin17levelsareassociatedwithnephritisinchildhoodonsetsystemiclupuserythematosus
AT sinicatonailuangelica seruminterleukin17levelsareassociatedwithnephritisinchildhoodonsetsystemiclupuserythematosus
AT peresfernandoaugusto seruminterleukin17levelsareassociatedwithnephritisinchildhoodonsetsystemiclupuserythematosus
AT fernandespaulateixeira seruminterleukin17levelsareassociatedwithnephritisinchildhoodonsetsystemiclupuserythematosus
AT mariniroberto seruminterleukin17levelsareassociatedwithnephritisinchildhoodonsetsystemiclupuserythematosus
AT costallatlilianterezalavras seruminterleukin17levelsareassociatedwithnephritisinchildhoodonsetsystemiclupuserythematosus
AT appenzellersimone seruminterleukin17levelsareassociatedwithnephritisinchildhoodonsetsystemiclupuserythematosus