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Prevention of fatal hepatic complication in schistosomiasis by inhibition of CETP

Schistosoma japonicum, once endemic all the East Asia, remains as a serious public health problem in certain regions. Ectopic egg embryonation in the liver causes granulomatosis and eventually fatal cirrhosis, so that prevention of this process is one of the keys to reduce its mortality. The embryon...

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Autores principales: Yokoyama, Shinji, Okumura-Noji, Kuniko, Lu, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449486/
https://www.ncbi.nlm.nih.gov/pubmed/26060442
http://dx.doi.org/10.7555/JBR.29.20150005
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author Yokoyama, Shinji
Okumura-Noji, Kuniko
Lu, Rui
author_facet Yokoyama, Shinji
Okumura-Noji, Kuniko
Lu, Rui
author_sort Yokoyama, Shinji
collection PubMed
description Schistosoma japonicum, once endemic all the East Asia, remains as a serious public health problem in certain regions. Ectopic egg embryonation in the liver causes granulomatosis and eventually fatal cirrhosis, so that prevention of this process is one of the keys to reduce its mortality. The embryonation requires cholesteryl ester from HDL of the host blood for egg yolk formation, and this reaction is impaired from the abnormal large HDL in genetic cholesteryl ester transfer protein (CETP) deficiency. When CETP was expressed in mice that otherwise lack this protein, granulomatosis of the liver was shown increased compared to the wild type upon infection of Schistosoma japonicum. The CETP deficiencies accumulated exclusively in East Asia, from Indochina to Siberia, so that Shistosomiasis can be a screening factor for this accumulation. CD36 related protein (CD36RP) was identified as a protein for this reaction, cloned from the cDNA library of Schistosoma japonicum with 1880-bp encoding 506 amino acids. The antibody against the extracellular loop of CD36RP inhibited cholesteryl ester uptake from HDL and suppressed egg embryonation in culture. Therefore, inhibition of CETP is a potential approach to prevent liver granulomatosis and thereby fatal liver cirrhosis in the infection of Schistosoma japonicum.
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spelling pubmed-44494862015-06-09 Prevention of fatal hepatic complication in schistosomiasis by inhibition of CETP Yokoyama, Shinji Okumura-Noji, Kuniko Lu, Rui J Biomed Res Review Article Schistosoma japonicum, once endemic all the East Asia, remains as a serious public health problem in certain regions. Ectopic egg embryonation in the liver causes granulomatosis and eventually fatal cirrhosis, so that prevention of this process is one of the keys to reduce its mortality. The embryonation requires cholesteryl ester from HDL of the host blood for egg yolk formation, and this reaction is impaired from the abnormal large HDL in genetic cholesteryl ester transfer protein (CETP) deficiency. When CETP was expressed in mice that otherwise lack this protein, granulomatosis of the liver was shown increased compared to the wild type upon infection of Schistosoma japonicum. The CETP deficiencies accumulated exclusively in East Asia, from Indochina to Siberia, so that Shistosomiasis can be a screening factor for this accumulation. CD36 related protein (CD36RP) was identified as a protein for this reaction, cloned from the cDNA library of Schistosoma japonicum with 1880-bp encoding 506 amino acids. The antibody against the extracellular loop of CD36RP inhibited cholesteryl ester uptake from HDL and suppressed egg embryonation in culture. Therefore, inhibition of CETP is a potential approach to prevent liver granulomatosis and thereby fatal liver cirrhosis in the infection of Schistosoma japonicum. Editorial Department of Journal of Biomedical Research 2015-05 2015-04-15 /pmc/articles/PMC4449486/ /pubmed/26060442 http://dx.doi.org/10.7555/JBR.29.20150005 Text en 2015 the Journal of Biomedical Research. All rights reserved.
spellingShingle Review Article
Yokoyama, Shinji
Okumura-Noji, Kuniko
Lu, Rui
Prevention of fatal hepatic complication in schistosomiasis by inhibition of CETP
title Prevention of fatal hepatic complication in schistosomiasis by inhibition of CETP
title_full Prevention of fatal hepatic complication in schistosomiasis by inhibition of CETP
title_fullStr Prevention of fatal hepatic complication in schistosomiasis by inhibition of CETP
title_full_unstemmed Prevention of fatal hepatic complication in schistosomiasis by inhibition of CETP
title_short Prevention of fatal hepatic complication in schistosomiasis by inhibition of CETP
title_sort prevention of fatal hepatic complication in schistosomiasis by inhibition of cetp
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449486/
https://www.ncbi.nlm.nih.gov/pubmed/26060442
http://dx.doi.org/10.7555/JBR.29.20150005
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