Cargando…

Experimental acute lung injury induces multi-organ epigenetic modifications in key angiogenic genes implicated in sepsis-associated endothelial dysfunction

INTRODUCTION: The Tie2/angiopoietin (Tie2/Ang) and vascular endothelial growth factor receptor-ligand systems (VEGFR/VEGF) are recognized to play important roles in the regulation of microvascular endothelial function. Downregulation of these genes during sepsis has been implicated in the pathogenes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bomsztyk, Karol, Mar, Daniel, An, Dowon, Sharifian, Roya, Mikula, Michal, Gharib, Sina A, Altemeier, William A, Liles, W Conrad, Denisenko, Oleg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449602/ https://www.ncbi.nlm.nih.gov/pubmed/25959381 http://dx.doi.org/10.1186/s13054-015-0943-4

Ejemplares similares

Distinct patterns of transcriptional and epigenetic alterations characterize acute and chronic kidney injury
por: Sharifian, Roya, et al.
Publicado: (2018)

Heterogeneity of epigenetic changes at ischemia/reperfusion- and endotoxin-induced acute kidney injury genes
por: Mar, Daniel, et al.
Publicado: (2015)

CryoGrid-PIXUL-RNA: high throughput RNA isolation platform for tissue transcript analysis
por: Schactler, Scott A., et al.
Publicado: (2023)

Synchronous Recruitment of Epigenetic Modifiers to Endotoxin Synergistically Activated Tnf-α Gene in Acute Kidney Injury
por: Bomsztyk, Karol, et al.
Publicado: (2013)

Chromatin changes trigger laminin genes dysregulation in aging kidneys
por: Denisenko, Oleg, et al.
Publicado: (2018)

Single cell epigenetic visualization assay
por: Kint, Sam, et al.
Publicado: (2021)

Multi-Organ Transcriptome Dynamics in a Mouse Model of Cecal Ligation and Puncture-Induced Polymicrobial Sepsis
por: Rumienczyk, Izabela, et al.
Publicado: (2021)

Fast chromatin immunoprecipitation assay
por: Nelson, Joel D., et al.
Publicado: (2006)

PIXUL-ChIP: integrated high-throughput sample preparation and analytical platform for epigenetic studies
por: Bomsztyk, Karol, et al.
Publicado: (2019)

Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis
por: Mikula, Michal, et al.
Publicado: (2015)

Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation
por: Denisenko, Oleg, et al.
Publicado: (2016)

Microplate-based chromatin immunoprecipitation method, Matrix ChIP: a platform to study signaling of complex genomic events
por: Flanagin, Steve, et al.
Publicado: (2008)

Effect of lung pericyte-like cell ablation on the bleomycin model of injury and repair
por: Hung, Chi F., et al.
Publicado: (2022)

Editorial: Endothelial activation and microcirculatory disorders in sepsis and critical illness
por: Joffre, Jérémie, et al.
Publicado: (2023)

Lung pericytes as mediators of inflammation
por: Rayner, Samuel G., et al.
Publicado: (2023)

Losartan reverses permissive epigenetic changes in renal glomeruli of diabetic db/db mice
por: Reddy, Marpadga A., et al.
Publicado: (2013)

Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology
por: Sacco, Antonio, et al.
Publicado: (2010)

Redox Components: Key Regulators of Epigenetic Modifications in Plants
por: R. M., Saravana Kumar, et al.
Publicado: (2020)

Epigenetic mechanisms of Immune remodeling in sepsis: targeting histone modification
por: Wu, Dan, et al.
Publicado: (2023)

Epigenetic regulation of histone modifications and Gata6 gene expression induced by maternal diet in mouse embryoid bodies in a model of developmental programming
por: Sun, Congshan, et al.
Publicado: (2015)

Halogenated imidazole derivatives block RNA polymerase II elongation along mitogen inducible genes
por: Mikula, Michal, et al.
Publicado: (2010)

Epigenetic modifications: Key players in cancer heterogeneity and drug resistance
por: Sadida, Hana Q., et al.
Publicado: (2023)

Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review
por: Xing, Katharine, et al.
Publicado: (2012)

Mechanical ventilation modulates Toll-like receptor-3-induced lung inflammation via a MyD88-dependent, TLR4-independent pathway: a controlled animal study
por: Chun, Carrie D, et al.
Publicado: (2010)

Ischemia-Reperfusion Lung Injury Is Attenuated in MyD88-Deficient Mice
por: Altemeier, William A., et al.
Publicado: (2013)

Editing of hnRNP K protein mRNA in colorectal adenocarcinoma and surrounding mucosa
por: Klimek-Tomczak, K, et al.
Publicado: (2006)

Epigenetic Modification: A Key Tool for Secondary Metabolite Production in Microorganisms
por: Bind, Sudha, et al.
Publicado: (2022)

Key Markers and Epigenetic Modifications of Dental-Derived Mesenchymal Stromal Cells
por: Chen, Jingqiu, et al.
Publicado: (2021)

Neutrophil extracellular traps (NETs) are increased in the alveolar spaces of patients with ventilator-associated pneumonia
por: Mikacenic, Carmen, et al.
Publicado: (2018)

Epigenetic Regulation of the Vascular Endothelium by Angiogenic LncRNAs
por: Subramaniam, Noeline, et al.
Publicado: (2021)

Is Syndecan-2 a Key Angiogenic Element?
por: Noguer, Oriol, et al.
Publicado: (2009)

Epigenetic Activation of Pro-angiogenic Signaling Pathways in Human Endothelial Progenitors Increases Vasculogenesis
por: Fraineau, Sylvain, et al.
Publicado: (2017)

The angiogenic factors and their soluble receptors in sepsis: friend, foe, or both?
por: Zhang, Ru-Yuan, et al.
Publicado: (2013)

Angiogenic factors in sepsis: are we ready for the new therapeutic era?
por: Zhang, Ru-Yuan, et al.
Publicado: (2014)

Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero
por: Rotroff, Daniel M., et al.
Publicado: (2016)

Epigenetic regulation of autophagy: A key modification in cancer cells and cancer stem cells
por: Mandhair, Harpreet K, et al.
Publicado: (2021)

Prognosis and Novel Drug Targets for Key lncRNAs of Epigenetic Modification in Colorectal Cancer
por: Zhang, Peng, et al.
Publicado: (2023)

Chromatin structure of two genomic sites for targeted transgene integration in induced pluripotent stem cells and hematopoietic stem cells
por: van Rensburg, Ruan, et al.
Publicado: (2012)

Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models
por: Kopczynski, Michal, et al.
Publicado: (2021)

Histone Modifications Represent a Key Epigenetic Feature of Epithelial-to-Mesenchyme Transition in Pancreatic Cancer
por: Xu, Ying, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_64d5skcsdj93faucruighk5ksd