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Consequences of Abdominal Adiposity within the Metabolic Syndrome Paradigm in Black People of African Ancestry
The metabolic syndrome (MetS) is a constellation of risk factors that are associated with increased risks for coronary heart disease and type 2 diabetes. Although the cause is unknown, abdominal adiposity is considered the underpinning of these metabolic alterations. Hence, increased abdominal adipo...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449646/ https://www.ncbi.nlm.nih.gov/pubmed/26237484 http://dx.doi.org/10.3390/jcm3030897 |
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author | Gaillard, Trudy |
author_facet | Gaillard, Trudy |
author_sort | Gaillard, Trudy |
collection | PubMed |
description | The metabolic syndrome (MetS) is a constellation of risk factors that are associated with increased risks for coronary heart disease and type 2 diabetes. Although the cause is unknown, abdominal adiposity is considered the underpinning of these metabolic alterations. Hence, increased abdominal adiposity contributes to dyslipidemia, hyperglycemia, beta cell dysfunction, insulin resistance, hypertension and inflammation. The role of abdominal adiposity in the causation of metabolic alterations that lead to the clinical expression of the MetS has become a focus of active research. In addition, there are ethnic/racial differences in the manifestation of the MetS. Therefore, the focus of this current review is to: (1) explore the consequences of abdominal obesity within the MetS paradigm; and (2) discuss the impact of ethnicity/race on MetS in Black People of African Ancestry (PAA). |
format | Online Article Text |
id | pubmed-4449646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-44496462015-07-28 Consequences of Abdominal Adiposity within the Metabolic Syndrome Paradigm in Black People of African Ancestry Gaillard, Trudy J Clin Med Review The metabolic syndrome (MetS) is a constellation of risk factors that are associated with increased risks for coronary heart disease and type 2 diabetes. Although the cause is unknown, abdominal adiposity is considered the underpinning of these metabolic alterations. Hence, increased abdominal adiposity contributes to dyslipidemia, hyperglycemia, beta cell dysfunction, insulin resistance, hypertension and inflammation. The role of abdominal adiposity in the causation of metabolic alterations that lead to the clinical expression of the MetS has become a focus of active research. In addition, there are ethnic/racial differences in the manifestation of the MetS. Therefore, the focus of this current review is to: (1) explore the consequences of abdominal obesity within the MetS paradigm; and (2) discuss the impact of ethnicity/race on MetS in Black People of African Ancestry (PAA). MDPI 2014-08-13 /pmc/articles/PMC4449646/ /pubmed/26237484 http://dx.doi.org/10.3390/jcm3030897 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Gaillard, Trudy Consequences of Abdominal Adiposity within the Metabolic Syndrome Paradigm in Black People of African Ancestry |
title | Consequences of Abdominal Adiposity within the Metabolic Syndrome Paradigm in Black People of African Ancestry |
title_full | Consequences of Abdominal Adiposity within the Metabolic Syndrome Paradigm in Black People of African Ancestry |
title_fullStr | Consequences of Abdominal Adiposity within the Metabolic Syndrome Paradigm in Black People of African Ancestry |
title_full_unstemmed | Consequences of Abdominal Adiposity within the Metabolic Syndrome Paradigm in Black People of African Ancestry |
title_short | Consequences of Abdominal Adiposity within the Metabolic Syndrome Paradigm in Black People of African Ancestry |
title_sort | consequences of abdominal adiposity within the metabolic syndrome paradigm in black people of african ancestry |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449646/ https://www.ncbi.nlm.nih.gov/pubmed/26237484 http://dx.doi.org/10.3390/jcm3030897 |
work_keys_str_mv | AT gaillardtrudy consequencesofabdominaladipositywithinthemetabolicsyndromeparadigminblackpeopleofafricanancestry |