Cargando…

The Incidence of Epstein-Barr Virus Primary Infection Among Suspected Patients Referred to Namazi Hospital of Shiraz, Iran

BACKGROUND: Many children become infected with Epstein-Barr virus (EBV) during their childhood. Since the clinical profile of EBV primary infection is challenging, it is important to use the best diagnostic clinical means. Detection of IgM against viral capsid antigen (VCA) by ELISA has been shown t...

Descripción completa

Detalles Bibliográficos
Autores principales: Moeini, Mahsa, Ziyaeyan, Mazyar, Asaei, Sadaf, Behzadi, Mohammad Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449844/
https://www.ncbi.nlm.nih.gov/pubmed/26034534
http://dx.doi.org/10.5812/jjm.8(4)2015.16109
_version_ 1782373912246484992
author Moeini, Mahsa
Ziyaeyan, Mazyar
Asaei, Sadaf
Behzadi, Mohammad Amin
author_facet Moeini, Mahsa
Ziyaeyan, Mazyar
Asaei, Sadaf
Behzadi, Mohammad Amin
author_sort Moeini, Mahsa
collection PubMed
description BACKGROUND: Many children become infected with Epstein-Barr virus (EBV) during their childhood. Since the clinical profile of EBV primary infection is challenging, it is important to use the best diagnostic clinical means. Detection of IgM against viral capsid antigen (VCA) by ELISA has been shown to be a reliable method. OBJECTIVES: This study was conducted to demonstrate the incidence of EBV primary infection, among suspected patients referred to Namazi hospital, Shiraz, Iran. PATIENTS AND METHODS: The sample included 346 patients with an age range of 0 to 20 years (6.31 ± 4.66: 10.97 years). A volume of 5 mL of blood was collected from each case. The patients were divided to four age groups. The sera were tested for the presence of VCA-IgM by commercially available Anti-EBV-VCA ELISA kit. RESULTS: The results indicated that 104 (30.0%) of the patients were EBV VCA IgM positive, with no significant difference in the incidence of EBV primary infection between males and females. However, the incidence of infection was significantly different between age group I (0 - 5 years) and III (11 - 15 years), and also between age group I (0 - 5 years) and IV (16 - 20 years) (P < 0.05). CONCLUSIONS: Considering the results, accurate and on time diagnosis of EBV primary infection in both children and adolescents will help prevent unnecessary hospitalization, medication and incorrect medical decisions. In addition, this will decrease further treatment costs and related medical procedures.
format Online
Article
Text
id pubmed-4449844
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Kowsar
record_format MEDLINE/PubMed
spelling pubmed-44498442015-06-01 The Incidence of Epstein-Barr Virus Primary Infection Among Suspected Patients Referred to Namazi Hospital of Shiraz, Iran Moeini, Mahsa Ziyaeyan, Mazyar Asaei, Sadaf Behzadi, Mohammad Amin Jundishapur J Microbiol Research Article BACKGROUND: Many children become infected with Epstein-Barr virus (EBV) during their childhood. Since the clinical profile of EBV primary infection is challenging, it is important to use the best diagnostic clinical means. Detection of IgM against viral capsid antigen (VCA) by ELISA has been shown to be a reliable method. OBJECTIVES: This study was conducted to demonstrate the incidence of EBV primary infection, among suspected patients referred to Namazi hospital, Shiraz, Iran. PATIENTS AND METHODS: The sample included 346 patients with an age range of 0 to 20 years (6.31 ± 4.66: 10.97 years). A volume of 5 mL of blood was collected from each case. The patients were divided to four age groups. The sera were tested for the presence of VCA-IgM by commercially available Anti-EBV-VCA ELISA kit. RESULTS: The results indicated that 104 (30.0%) of the patients were EBV VCA IgM positive, with no significant difference in the incidence of EBV primary infection between males and females. However, the incidence of infection was significantly different between age group I (0 - 5 years) and III (11 - 15 years), and also between age group I (0 - 5 years) and IV (16 - 20 years) (P < 0.05). CONCLUSIONS: Considering the results, accurate and on time diagnosis of EBV primary infection in both children and adolescents will help prevent unnecessary hospitalization, medication and incorrect medical decisions. In addition, this will decrease further treatment costs and related medical procedures. Kowsar 2015-04-18 /pmc/articles/PMC4449844/ /pubmed/26034534 http://dx.doi.org/10.5812/jjm.8(4)2015.16109 Text en Copyright © 2015, Ahvaz Jundishapur University of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Moeini, Mahsa
Ziyaeyan, Mazyar
Asaei, Sadaf
Behzadi, Mohammad Amin
The Incidence of Epstein-Barr Virus Primary Infection Among Suspected Patients Referred to Namazi Hospital of Shiraz, Iran
title The Incidence of Epstein-Barr Virus Primary Infection Among Suspected Patients Referred to Namazi Hospital of Shiraz, Iran
title_full The Incidence of Epstein-Barr Virus Primary Infection Among Suspected Patients Referred to Namazi Hospital of Shiraz, Iran
title_fullStr The Incidence of Epstein-Barr Virus Primary Infection Among Suspected Patients Referred to Namazi Hospital of Shiraz, Iran
title_full_unstemmed The Incidence of Epstein-Barr Virus Primary Infection Among Suspected Patients Referred to Namazi Hospital of Shiraz, Iran
title_short The Incidence of Epstein-Barr Virus Primary Infection Among Suspected Patients Referred to Namazi Hospital of Shiraz, Iran
title_sort incidence of epstein-barr virus primary infection among suspected patients referred to namazi hospital of shiraz, iran
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449844/
https://www.ncbi.nlm.nih.gov/pubmed/26034534
http://dx.doi.org/10.5812/jjm.8(4)2015.16109
work_keys_str_mv AT moeinimahsa theincidenceofepsteinbarrvirusprimaryinfectionamongsuspectedpatientsreferredtonamazihospitalofshiraziran
AT ziyaeyanmazyar theincidenceofepsteinbarrvirusprimaryinfectionamongsuspectedpatientsreferredtonamazihospitalofshiraziran
AT asaeisadaf theincidenceofepsteinbarrvirusprimaryinfectionamongsuspectedpatientsreferredtonamazihospitalofshiraziran
AT behzadimohammadamin theincidenceofepsteinbarrvirusprimaryinfectionamongsuspectedpatientsreferredtonamazihospitalofshiraziran
AT moeinimahsa incidenceofepsteinbarrvirusprimaryinfectionamongsuspectedpatientsreferredtonamazihospitalofshiraziran
AT ziyaeyanmazyar incidenceofepsteinbarrvirusprimaryinfectionamongsuspectedpatientsreferredtonamazihospitalofshiraziran
AT asaeisadaf incidenceofepsteinbarrvirusprimaryinfectionamongsuspectedpatientsreferredtonamazihospitalofshiraziran
AT behzadimohammadamin incidenceofepsteinbarrvirusprimaryinfectionamongsuspectedpatientsreferredtonamazihospitalofshiraziran