Curcumin and Its Analogue Induce Apoptosis in Leukemia Cells and Have Additive Effects with Bortezomib in Cellular and Xenograft Models

Combination therapy of bortezomib with other chemotherapeutics is an emerging treatment strategy. Since both curcumin and bortezomib inhibit NF-κB, we tested the effects of their combination on leukemia cells. To improve potency, a novel Mannich-type curcumin derivative, C-150, was synthesized. Curc...

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Detalles Bibliográficos
Autores principales: Nagy, L. I., Fehér, L. Z., Szebeni, G. J., Gyuris, M., Sipos, P., Alföldi, R., Ózsvári, B., Hackler, L., Balázs, A., Batár, P., Kanizsai, I., Puskás, L. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449904/
https://www.ncbi.nlm.nih.gov/pubmed/26075279
http://dx.doi.org/10.1155/2015/968981

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