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Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine

Recent studies demonstrated that mitochondria play an important role in the cardiovascular system and mutations of mitochondrial DNA affect coronary artery disease, resulting in hypertension, atherosclerosis, and cardiomyopathy. Traditional Chinese medicine (TCM) has been used for thousands of years...

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Autores principales: Wang, Jie, Lin, Fei, Guo, Li-li, Xiong, Xing-jiang, Fan, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449907/
https://www.ncbi.nlm.nih.gov/pubmed/26074984
http://dx.doi.org/10.1155/2015/143145
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author Wang, Jie
Lin, Fei
Guo, Li-li
Xiong, Xing-jiang
Fan, Xun
author_facet Wang, Jie
Lin, Fei
Guo, Li-li
Xiong, Xing-jiang
Fan, Xun
author_sort Wang, Jie
collection PubMed
description Recent studies demonstrated that mitochondria play an important role in the cardiovascular system and mutations of mitochondrial DNA affect coronary artery disease, resulting in hypertension, atherosclerosis, and cardiomyopathy. Traditional Chinese medicine (TCM) has been used for thousands of years to treat cardiovascular disease, but it is not yet clear how TCM affects mitochondrial function. By reviewing the interactions between the cardiovascular system, mitochondrial DNA, and TCM, we show that cardiovascular disease is negatively affected by mutations in mitochondrial DNA and that TCM can be used to treat cardiovascular disease by regulating the structure and function of mitochondria via increases in mitochondrial electron transport and oxidative phosphorylation, modulation of mitochondrial-mediated apoptosis, and decreases in mitochondrial ROS. However further research is still required to identify the mechanism by which TCM affects CVD and modifies mitochondrial DNA.
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spelling pubmed-44499072015-06-14 Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine Wang, Jie Lin, Fei Guo, Li-li Xiong, Xing-jiang Fan, Xun Evid Based Complement Alternat Med Review Article Recent studies demonstrated that mitochondria play an important role in the cardiovascular system and mutations of mitochondrial DNA affect coronary artery disease, resulting in hypertension, atherosclerosis, and cardiomyopathy. Traditional Chinese medicine (TCM) has been used for thousands of years to treat cardiovascular disease, but it is not yet clear how TCM affects mitochondrial function. By reviewing the interactions between the cardiovascular system, mitochondrial DNA, and TCM, we show that cardiovascular disease is negatively affected by mutations in mitochondrial DNA and that TCM can be used to treat cardiovascular disease by regulating the structure and function of mitochondria via increases in mitochondrial electron transport and oxidative phosphorylation, modulation of mitochondrial-mediated apoptosis, and decreases in mitochondrial ROS. However further research is still required to identify the mechanism by which TCM affects CVD and modifies mitochondrial DNA. Hindawi Publishing Corporation 2015 2015-05-17 /pmc/articles/PMC4449907/ /pubmed/26074984 http://dx.doi.org/10.1155/2015/143145 Text en Copyright © 2015 Jie Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Jie
Lin, Fei
Guo, Li-li
Xiong, Xing-jiang
Fan, Xun
Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine
title Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine
title_full Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine
title_fullStr Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine
title_full_unstemmed Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine
title_short Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine
title_sort cardiovascular disease, mitochondria, and traditional chinese medicine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449907/
https://www.ncbi.nlm.nih.gov/pubmed/26074984
http://dx.doi.org/10.1155/2015/143145
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