Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models

This research was carried out to investigate the thrombolytic effects of the methanolic extracts of five Bangladeshi plants. Phytochemical metabolites of those plants have been identified to elucidate whether the plant-derived metabolites are linked with the thrombolytic effects. Potential computer...

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Autores principales: Mahmud, Sakib, Akhter, Samina, Rahman, Md. Atiar, Aklima, Jannatul, Akhter, Shaheen, Merry, Syeeda Rayhana, Jubair, S. M. Rakibul, Dash, Raju, Emran, Talha Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449917/
https://www.ncbi.nlm.nih.gov/pubmed/26075001
http://dx.doi.org/10.1155/2015/782742
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author Mahmud, Sakib
Akhter, Samina
Rahman, Md. Atiar
Aklima, Jannatul
Akhter, Shaheen
Merry, Syeeda Rayhana
Jubair, S. M. Rakibul
Dash, Raju
Emran, Talha Bin
author_facet Mahmud, Sakib
Akhter, Samina
Rahman, Md. Atiar
Aklima, Jannatul
Akhter, Shaheen
Merry, Syeeda Rayhana
Jubair, S. M. Rakibul
Dash, Raju
Emran, Talha Bin
author_sort Mahmud, Sakib
collection PubMed
description This research was carried out to investigate the thrombolytic effects of the methanolic extracts of five Bangladeshi plants. Phytochemical metabolites of those plants have been identified to elucidate whether the plant-derived metabolites are linked with the thrombolytic effects. Potential computer aided models were adopted in this study to find out a structure-function correlation between the phytochemical constituents and thrombolytic effects using the secondary metabolites as ligands and tissue plasminogen activator (t-PA) as receptor for the best fit ligand-receptor interaction.
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spelling pubmed-44499172015-06-14 Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models Mahmud, Sakib Akhter, Samina Rahman, Md. Atiar Aklima, Jannatul Akhter, Shaheen Merry, Syeeda Rayhana Jubair, S. M. Rakibul Dash, Raju Emran, Talha Bin Evid Based Complement Alternat Med Research Article This research was carried out to investigate the thrombolytic effects of the methanolic extracts of five Bangladeshi plants. Phytochemical metabolites of those plants have been identified to elucidate whether the plant-derived metabolites are linked with the thrombolytic effects. Potential computer aided models were adopted in this study to find out a structure-function correlation between the phytochemical constituents and thrombolytic effects using the secondary metabolites as ligands and tissue plasminogen activator (t-PA) as receptor for the best fit ligand-receptor interaction. Hindawi Publishing Corporation 2015 2015-05-17 /pmc/articles/PMC4449917/ /pubmed/26075001 http://dx.doi.org/10.1155/2015/782742 Text en Copyright © 2015 Sakib Mahmud et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mahmud, Sakib
Akhter, Samina
Rahman, Md. Atiar
Aklima, Jannatul
Akhter, Shaheen
Merry, Syeeda Rayhana
Jubair, S. M. Rakibul
Dash, Raju
Emran, Talha Bin
Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models
title Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models
title_full Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models
title_fullStr Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models
title_full_unstemmed Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models
title_short Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models
title_sort antithrombotic effects of five organic extracts of bangladeshi plants in vitro and mechanisms in in silico models
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449917/
https://www.ncbi.nlm.nih.gov/pubmed/26075001
http://dx.doi.org/10.1155/2015/782742
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