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Evidence for the Role of Blue Light in the Development of Uveal Melanoma
Uveal melanoma is the most common malignancy of the adult eye. Although it is a relatively infrequent tumor, clinical prognosis is often poor owing to a high incidence of aggressive metastatic disease, for which there are limited treatment options. Little is known about the etiology of this conditio...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449937/ https://www.ncbi.nlm.nih.gov/pubmed/26075084 http://dx.doi.org/10.1155/2015/386986 |
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author | Logan, Patrick Bernabeu, Miguel Ferreira, Alberto Burnier, Miguel N. |
author_facet | Logan, Patrick Bernabeu, Miguel Ferreira, Alberto Burnier, Miguel N. |
author_sort | Logan, Patrick |
collection | PubMed |
description | Uveal melanoma is the most common malignancy of the adult eye. Although it is a relatively infrequent tumor, clinical prognosis is often poor owing to a high incidence of aggressive metastatic disease, for which there are limited treatment options. Little is known about the etiology of this condition, although several risk factors have been identified. Unlike cutaneous melanoma, however, ultraviolet radiation does not figure prominently among these risk factors. In this review, we focus on an associated form of visible electromagnetic radiation, high-energy short-wave (blue) light, a causative agent in various forms of age-related retina damage, as a previously overlooked risk factor in uveal melanoma development and progression. Finally, we discuss the impact of these data on contemporary ocular therapy, particularly the debate surrounding the filtering capabilities of intraocular lenses used to replace dysfunctional crystalline lenses during cataract surgery. |
format | Online Article Text |
id | pubmed-4449937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44499372015-06-14 Evidence for the Role of Blue Light in the Development of Uveal Melanoma Logan, Patrick Bernabeu, Miguel Ferreira, Alberto Burnier, Miguel N. J Ophthalmol Review Article Uveal melanoma is the most common malignancy of the adult eye. Although it is a relatively infrequent tumor, clinical prognosis is often poor owing to a high incidence of aggressive metastatic disease, for which there are limited treatment options. Little is known about the etiology of this condition, although several risk factors have been identified. Unlike cutaneous melanoma, however, ultraviolet radiation does not figure prominently among these risk factors. In this review, we focus on an associated form of visible electromagnetic radiation, high-energy short-wave (blue) light, a causative agent in various forms of age-related retina damage, as a previously overlooked risk factor in uveal melanoma development and progression. Finally, we discuss the impact of these data on contemporary ocular therapy, particularly the debate surrounding the filtering capabilities of intraocular lenses used to replace dysfunctional crystalline lenses during cataract surgery. Hindawi Publishing Corporation 2015 2015-05-17 /pmc/articles/PMC4449937/ /pubmed/26075084 http://dx.doi.org/10.1155/2015/386986 Text en Copyright © 2015 Patrick Logan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Logan, Patrick Bernabeu, Miguel Ferreira, Alberto Burnier, Miguel N. Evidence for the Role of Blue Light in the Development of Uveal Melanoma |
title | Evidence for the Role of Blue Light in the Development of Uveal Melanoma |
title_full | Evidence for the Role of Blue Light in the Development of Uveal Melanoma |
title_fullStr | Evidence for the Role of Blue Light in the Development of Uveal Melanoma |
title_full_unstemmed | Evidence for the Role of Blue Light in the Development of Uveal Melanoma |
title_short | Evidence for the Role of Blue Light in the Development of Uveal Melanoma |
title_sort | evidence for the role of blue light in the development of uveal melanoma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449937/ https://www.ncbi.nlm.nih.gov/pubmed/26075084 http://dx.doi.org/10.1155/2015/386986 |
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