Cargando…

Pharmacokinetic Study and Optimal Formulation of New Anti-Parkinson Natural Compound Schisantherin A

Our recent studies showed that schisantherin A (StA) is a promising candidate for PD treatment, but the pharmacokinetic profile of StA is largely unknown. The effects of different formulations on the pharmacokinetics and bioavailability of StA were investigated by HPLC equipped with a vacuum degasse...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sa, Fei, Guo, Bao Jian, Li, Sai, Zhang, Zai Jun, Chan, Hok Man, Zheng, Ying, Lee, Simon Ming Yuen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449939/ https://www.ncbi.nlm.nih.gov/pubmed/26075137 http://dx.doi.org/10.1155/2015/951361

Ejemplares similares

Research Progress on the Pharmacological Action of Schisantherin A
por: Xiao, Zehao, et al.
Publicado: (2022)

Protective Role of Deoxyschizandrin and Schisantherin A against Myocardial Ischemia–Reperfusion Injury in Rats
por: Chang, Ruimiao, et al.
Publicado: (2013)

Schisantherin A inhibits cell proliferation by regulating glucose metabolism pathway in hepatocellular carcinoma
por: Feng, Fan, et al.
Publicado: (2022)

Schisantherin A alleviates non-alcoholic fatty liver disease by restoring intestinal barrier function
por: Yu, Shenglan, et al.
Publicado: (2022)

Investigation of the Impact of CYP3A5 Polymorphism on Drug–Drug Interaction between Tacrolimus and Schisantherin A/Schisandrin A Based on Physiologically-Based Pharmacokinetic Modeling
por: He, Qingfeng, et al.
Publicado: (2021)

Schisantherin B Improves the Pathological Manifestations of Mice Caused by Behavior Desperation in Different Ages-Depression with Cognitive Impairment
por: Xu, Mengjie, et al.
Publicado: (2019)

Schisantherin A alleviated alcohol-induced liver injury by the regulation of alcohol metabolism and NF-kB pathway
por: Li, Bin, et al.
Publicado: (2018)

Screening and Identification of the Main Metabolites of Schisantherin a In Vivo and In Vitro by Using UHPLC-Q-TOF-MS/MS
por: Feng, Wei, et al.
Publicado: (2020)

Schisantherin A improves learning and memory abilities partly through regulating the Nrf2/Keap1/ARE signaling pathway in chronic fatigue mice
por: Lin, Huijiao, et al.
Publicado: (2021)

Pharmacokinetics and pharmacodynamics of an orally disintegrating tablet formulation of dexlansoprazole
por: Kukulka, Michael, et al.
Publicado: (2016)

Advanced Bioinformatics Tools in the Pharmacokinetic Profiles of Natural and Synthetic Compounds with Anti-Diabetic Activity
por: Udrea, Ana Maria, et al.
Publicado: (2021)

Formulations, Hemolytic and Pharmacokinetic Studies on Saikosaponin a and Saikosaponin d Compound Liposomes
por: Zhang, Guo-Song, et al.
Publicado: (2015)

From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound
por: Hung, Ming Wai, et al.
Publicado: (2012)

Formulation, In Vitro and In Vivo Pharmacokinetics of Anti-HIV Vaginal Bioadhesive Gel
por: Chatterjee, A, et al.
Publicado: (2011)

Anti-inflammatory activity of Shirishavaleha: An Ayurvedic compound formulation
por: Yadav, Shyamlal Singh, et al.
Publicado: (2010)

Pharmacokinetics and optimized dosing of dispersible and non-dispersible levofloxacin formulations in young children
por: van der Laan, Louvina E, et al.
Publicado: (2023)

Pharmacokinetics of a liposomal formulation of doxorubicin in rats
por: Liu, Zongyu, et al.
Publicado: (2017)

Preparation and Pharmacokinetic Characterization of an Anti-Virulence Compound Nanosuspensions
por: Wang, Nan, et al.
Publicado: (2021)

Model-based optimization of controlled release formulation of levodopa for Parkinson’s disease
por: Arav, Yehuda, et al.
Publicado: (2023)

Anti depressant activity of Mamsyadi Kwatha: An Ayurvedic compound formulation
por: Shreevathsa, M., et al.
Publicado: (2013)

Preparation of finasteride capsules-loaded drug nanoparticles: formulation, optimization, in vitro, and pharmacokinetic evaluation
por: Ahmed, Tarek A
Publicado: (2016)

Formulation, Optimization, In Vitro and In Vivo Evaluation of Saxagliptin-Loaded Lipospheres for an Improved Pharmacokinetic Behavior
por: Rasul, Akhtar, et al.
Publicado: (2021)

IRE1α inhibition by natural compound genipin on tumour associated macrophages reduces growth of hepatocellular carcinoma
por: Tan, Hor-Yue, et al.
Publicado: (2016)

Microencapsulation and the Characterization of Polyherbal Formulation (PHF) Rich in Natural Polyphenolic Compounds
por: Hussain, Syed Ammar, et al.
Publicado: (2018)

Marine-Derived Natural Compounds for the Treatment of Parkinson’s Disease
por: Huang, Chunhui, et al.
Publicado: (2019)

Enhancement of the bioavailability of a novel anticancer compound (acetyltanshinone IIA) by encapsulation within mPEG-PLGA nanoparticles: a study of formulation optimization, toxicity, and pharmacokinetics
por: Wang, Qi, et al.
Publicado: (2017)

Intranasal agomelatine solid lipid nanoparticles to enhance brain delivery: formulation, optimization and in vivo pharmacokinetics
por: Fatouh, Ahmed M, et al.
Publicado: (2017)

Formulation and Optimization of Avanafil Biodegradable Polymeric Nanoparticles: A Single-Dose Clinical Pharmacokinetic Evaluation
por: Aldawsari, Hibah M., et al.
Publicado: (2020)

Towards optimal design of anti-malarial pharmacokinetic studies
por: Simpson, Julie A, et al.
Publicado: (2009)

Anti-Quorum Sensing Natural Compounds
por: Asfour, Hani Z.
Publicado: (2018)

The Anti-Leukemic Activity of Natural Compounds
por: Cotoraci, Coralia, et al.
Publicado: (2021)

Mycophenolic Acid for Topical Immunosuppression in Vascularized Composite Allotransplantation: Optimizing Formulation and Preliminary Evaluation of Bioavailability and Pharmacokinetics
por: Feturi, Firuz G., et al.
Publicado: (2018)

Model-Informed Optimization of a Pediatric Clinical Pharmacokinetic Trial of a New Spironolactone Liquid Formulation
por: Tatipalli, Manasa, et al.
Publicado: (2021)

Natural Compounds for the Management of Parkinson's Disease and Attention-Deficit/Hyperactivity Disorder
por: Corona, Juan Carlos
Publicado: (2018)

Anti-Pigmentary Natural Compounds and Their Mode of Action
por: Kim, Kyuri, et al.
Publicado: (2021)

Formulation Development and Optimization of Fast Dissolving Tablets of Aceclofenac Using Natural Superdisintegrant
por: Kaur, Lovleen, et al.
Publicado: (2014)

Formulation and Optimization of Nanoemulsions Using the Natural Surfactant Saponin from Quillaja Bark
por: Schreiner, Tatiana B., et al.
Publicado: (2020)

Intravenous microemulsion of docetaxel containing an anti-tumor synergistic ingredient (Brucea javanica oil): formulation and pharmacokinetics
por: Ma, Shilin, et al.
Publicado: (2013)

Polymorphic Characterization, Pharmacokinetics, and Anti-Inflammatory Activity of Ginsenoside Compound K Polymorphs
por: Kuang, Yun-Yan, et al.
Publicado: (2021)

Pharmacokinetics of five phthalides in volatile oil of Ligusticum sinense Oliv.cv. Chaxiong, and comparison study on physicochemistry and pharmacokinetics after being formulated into solid dispersion and inclusion compound
por: Hu, Peng-yi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_s86pc7salnhepf6m956sn6jkpi