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Apple Peel Supplemented Diet Reduces Parameters of Metabolic Syndrome and Atherogenic Progression in ApoE−/− Mice
Cardiovascular Diseases (CVD) represent about 30% of all causes of death worldwide. The development of CVD is related in many cases with the previous existence of metabolic syndrome (MS). It is known that apple consumption has a cardiovascular protecting effect, containing phenolic compounds with an...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449944/ https://www.ncbi.nlm.nih.gov/pubmed/26075004 http://dx.doi.org/10.1155/2015/918384 |
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author | Gonzalez, Jaime Donoso, Wendy Sandoval, Nathalie Reyes, María Gonzalez, Priscila Gajardo, Monica Morales, Erik Neira, Amalia Razmilic, Iván Yuri, José A. Moore-Carrasco, Rodrigo |
author_facet | Gonzalez, Jaime Donoso, Wendy Sandoval, Nathalie Reyes, María Gonzalez, Priscila Gajardo, Monica Morales, Erik Neira, Amalia Razmilic, Iván Yuri, José A. Moore-Carrasco, Rodrigo |
author_sort | Gonzalez, Jaime |
collection | PubMed |
description | Cardiovascular Diseases (CVD) represent about 30% of all causes of death worldwide. The development of CVD is related in many cases with the previous existence of metabolic syndrome (MS). It is known that apple consumption has a cardiovascular protecting effect, containing phenolic compounds with antioxidant effect, which are concentrated in the fruit peel. The objective of this study was to test the effect of apple peel consumption in a murine model of MS and apoE−/− mice. Apple supplemented diets reduced the biochemical parameters (glycaemia, total cholesterol, HDL-cholesterol, LDL-cholesterol, ureic nitrogen, triglycerides, insulin, and asymmetric dimethylarginine (ADMA)) of MS model in CF1 mice significantly. The model apoE−/− mouse was used to evaluate the capacity of the apple peel to revert the progression of the atherogenesis. FD with HAP reverts cholesterol significantly and slows down the progression of the plate diminishing the cholesterol accumulation area. With these results, it can be concluded that the consumption of apple peel reduces several MS parameters and the atherogenic progression in mice. |
format | Online Article Text |
id | pubmed-4449944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44499442015-06-14 Apple Peel Supplemented Diet Reduces Parameters of Metabolic Syndrome and Atherogenic Progression in ApoE−/− Mice Gonzalez, Jaime Donoso, Wendy Sandoval, Nathalie Reyes, María Gonzalez, Priscila Gajardo, Monica Morales, Erik Neira, Amalia Razmilic, Iván Yuri, José A. Moore-Carrasco, Rodrigo Evid Based Complement Alternat Med Research Article Cardiovascular Diseases (CVD) represent about 30% of all causes of death worldwide. The development of CVD is related in many cases with the previous existence of metabolic syndrome (MS). It is known that apple consumption has a cardiovascular protecting effect, containing phenolic compounds with antioxidant effect, which are concentrated in the fruit peel. The objective of this study was to test the effect of apple peel consumption in a murine model of MS and apoE−/− mice. Apple supplemented diets reduced the biochemical parameters (glycaemia, total cholesterol, HDL-cholesterol, LDL-cholesterol, ureic nitrogen, triglycerides, insulin, and asymmetric dimethylarginine (ADMA)) of MS model in CF1 mice significantly. The model apoE−/− mouse was used to evaluate the capacity of the apple peel to revert the progression of the atherogenesis. FD with HAP reverts cholesterol significantly and slows down the progression of the plate diminishing the cholesterol accumulation area. With these results, it can be concluded that the consumption of apple peel reduces several MS parameters and the atherogenic progression in mice. Hindawi Publishing Corporation 2015 2015-05-17 /pmc/articles/PMC4449944/ /pubmed/26075004 http://dx.doi.org/10.1155/2015/918384 Text en Copyright © 2015 Jaime Gonzalez et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Gonzalez, Jaime Donoso, Wendy Sandoval, Nathalie Reyes, María Gonzalez, Priscila Gajardo, Monica Morales, Erik Neira, Amalia Razmilic, Iván Yuri, José A. Moore-Carrasco, Rodrigo Apple Peel Supplemented Diet Reduces Parameters of Metabolic Syndrome and Atherogenic Progression in ApoE−/− Mice |
title | Apple Peel Supplemented Diet Reduces Parameters of Metabolic Syndrome and Atherogenic Progression in ApoE−/− Mice |
title_full | Apple Peel Supplemented Diet Reduces Parameters of Metabolic Syndrome and Atherogenic Progression in ApoE−/− Mice |
title_fullStr | Apple Peel Supplemented Diet Reduces Parameters of Metabolic Syndrome and Atherogenic Progression in ApoE−/− Mice |
title_full_unstemmed | Apple Peel Supplemented Diet Reduces Parameters of Metabolic Syndrome and Atherogenic Progression in ApoE−/− Mice |
title_short | Apple Peel Supplemented Diet Reduces Parameters of Metabolic Syndrome and Atherogenic Progression in ApoE−/− Mice |
title_sort | apple peel supplemented diet reduces parameters of metabolic syndrome and atherogenic progression in apoe−/− mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449944/ https://www.ncbi.nlm.nih.gov/pubmed/26075004 http://dx.doi.org/10.1155/2015/918384 |
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