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Strategies of Intracellular Pathogens for Obtaining Iron from the Environment
Most microorganisms are destroyed by the host tissues through processes that usually involve phagocytosis and lysosomal disruption. However, some organisms, called intracellular pathogens, are capable of avoiding destruction by growing inside macrophages or other cells. During infection with intrace...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450229/ https://www.ncbi.nlm.nih.gov/pubmed/26120582 http://dx.doi.org/10.1155/2015/476534 |
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author | Leon-Sicairos, Nidia Reyes-Cortes, Ruth Guadrón-Llanos, Alma M. Madueña-Molina, Jesús Leon-Sicairos, Claudia Canizalez-Román, Adrian |
author_facet | Leon-Sicairos, Nidia Reyes-Cortes, Ruth Guadrón-Llanos, Alma M. Madueña-Molina, Jesús Leon-Sicairos, Claudia Canizalez-Román, Adrian |
author_sort | Leon-Sicairos, Nidia |
collection | PubMed |
description | Most microorganisms are destroyed by the host tissues through processes that usually involve phagocytosis and lysosomal disruption. However, some organisms, called intracellular pathogens, are capable of avoiding destruction by growing inside macrophages or other cells. During infection with intracellular pathogenic microorganisms, the element iron is required by both the host cell and the pathogen that inhabits the host cell. This minireview focuses on how intracellular pathogens use multiple strategies to obtain nutritional iron from the intracellular environment in order to use this element for replication. Additionally, the implications of these mechanisms for iron acquisition in the pathogen-host relationship are discussed. |
format | Online Article Text |
id | pubmed-4450229 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44502292015-06-28 Strategies of Intracellular Pathogens for Obtaining Iron from the Environment Leon-Sicairos, Nidia Reyes-Cortes, Ruth Guadrón-Llanos, Alma M. Madueña-Molina, Jesús Leon-Sicairos, Claudia Canizalez-Román, Adrian Biomed Res Int Review Article Most microorganisms are destroyed by the host tissues through processes that usually involve phagocytosis and lysosomal disruption. However, some organisms, called intracellular pathogens, are capable of avoiding destruction by growing inside macrophages or other cells. During infection with intracellular pathogenic microorganisms, the element iron is required by both the host cell and the pathogen that inhabits the host cell. This minireview focuses on how intracellular pathogens use multiple strategies to obtain nutritional iron from the intracellular environment in order to use this element for replication. Additionally, the implications of these mechanisms for iron acquisition in the pathogen-host relationship are discussed. Hindawi Publishing Corporation 2015 2015-05-18 /pmc/articles/PMC4450229/ /pubmed/26120582 http://dx.doi.org/10.1155/2015/476534 Text en Copyright © 2015 Nidia Leon-Sicairos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Leon-Sicairos, Nidia Reyes-Cortes, Ruth Guadrón-Llanos, Alma M. Madueña-Molina, Jesús Leon-Sicairos, Claudia Canizalez-Román, Adrian Strategies of Intracellular Pathogens for Obtaining Iron from the Environment |
title | Strategies of Intracellular Pathogens for Obtaining Iron from the Environment |
title_full | Strategies of Intracellular Pathogens for Obtaining Iron from the Environment |
title_fullStr | Strategies of Intracellular Pathogens for Obtaining Iron from the Environment |
title_full_unstemmed | Strategies of Intracellular Pathogens for Obtaining Iron from the Environment |
title_short | Strategies of Intracellular Pathogens for Obtaining Iron from the Environment |
title_sort | strategies of intracellular pathogens for obtaining iron from the environment |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450229/ https://www.ncbi.nlm.nih.gov/pubmed/26120582 http://dx.doi.org/10.1155/2015/476534 |
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