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Strategies of Intracellular Pathogens for Obtaining Iron from the Environment

Most microorganisms are destroyed by the host tissues through processes that usually involve phagocytosis and lysosomal disruption. However, some organisms, called intracellular pathogens, are capable of avoiding destruction by growing inside macrophages or other cells. During infection with intrace...

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Autores principales: Leon-Sicairos, Nidia, Reyes-Cortes, Ruth, Guadrón-Llanos, Alma M., Madueña-Molina, Jesús, Leon-Sicairos, Claudia, Canizalez-Román, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450229/
https://www.ncbi.nlm.nih.gov/pubmed/26120582
http://dx.doi.org/10.1155/2015/476534
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author Leon-Sicairos, Nidia
Reyes-Cortes, Ruth
Guadrón-Llanos, Alma M.
Madueña-Molina, Jesús
Leon-Sicairos, Claudia
Canizalez-Román, Adrian
author_facet Leon-Sicairos, Nidia
Reyes-Cortes, Ruth
Guadrón-Llanos, Alma M.
Madueña-Molina, Jesús
Leon-Sicairos, Claudia
Canizalez-Román, Adrian
author_sort Leon-Sicairos, Nidia
collection PubMed
description Most microorganisms are destroyed by the host tissues through processes that usually involve phagocytosis and lysosomal disruption. However, some organisms, called intracellular pathogens, are capable of avoiding destruction by growing inside macrophages or other cells. During infection with intracellular pathogenic microorganisms, the element iron is required by both the host cell and the pathogen that inhabits the host cell. This minireview focuses on how intracellular pathogens use multiple strategies to obtain nutritional iron from the intracellular environment in order to use this element for replication. Additionally, the implications of these mechanisms for iron acquisition in the pathogen-host relationship are discussed.
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spelling pubmed-44502292015-06-28 Strategies of Intracellular Pathogens for Obtaining Iron from the Environment Leon-Sicairos, Nidia Reyes-Cortes, Ruth Guadrón-Llanos, Alma M. Madueña-Molina, Jesús Leon-Sicairos, Claudia Canizalez-Román, Adrian Biomed Res Int Review Article Most microorganisms are destroyed by the host tissues through processes that usually involve phagocytosis and lysosomal disruption. However, some organisms, called intracellular pathogens, are capable of avoiding destruction by growing inside macrophages or other cells. During infection with intracellular pathogenic microorganisms, the element iron is required by both the host cell and the pathogen that inhabits the host cell. This minireview focuses on how intracellular pathogens use multiple strategies to obtain nutritional iron from the intracellular environment in order to use this element for replication. Additionally, the implications of these mechanisms for iron acquisition in the pathogen-host relationship are discussed. Hindawi Publishing Corporation 2015 2015-05-18 /pmc/articles/PMC4450229/ /pubmed/26120582 http://dx.doi.org/10.1155/2015/476534 Text en Copyright © 2015 Nidia Leon-Sicairos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Leon-Sicairos, Nidia
Reyes-Cortes, Ruth
Guadrón-Llanos, Alma M.
Madueña-Molina, Jesús
Leon-Sicairos, Claudia
Canizalez-Román, Adrian
Strategies of Intracellular Pathogens for Obtaining Iron from the Environment
title Strategies of Intracellular Pathogens for Obtaining Iron from the Environment
title_full Strategies of Intracellular Pathogens for Obtaining Iron from the Environment
title_fullStr Strategies of Intracellular Pathogens for Obtaining Iron from the Environment
title_full_unstemmed Strategies of Intracellular Pathogens for Obtaining Iron from the Environment
title_short Strategies of Intracellular Pathogens for Obtaining Iron from the Environment
title_sort strategies of intracellular pathogens for obtaining iron from the environment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450229/
https://www.ncbi.nlm.nih.gov/pubmed/26120582
http://dx.doi.org/10.1155/2015/476534
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