Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development

We examined genetic and epigenetic changes that occur during disease progression from indolent to aggressive forms of chronic lymphocytic leukemia (CLL) using serial samples from 27 patients. Analysis of DNA mutations grouped the leukemia cases into three categories: evolving (26%), expanding (26%)...

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Detalles Bibliográficos
Autores principales: Smith, E N, Ghia, E M, DeBoever, C M, Rassenti, L Z, Jepsen, K, Yoon, K-A, Matsui, H, Rozenzhak, S, Alakus, H, Shepard, P J, Dai, Y, Khosroheidari, M, Bina, M, Gunderson, K L, Messer, K, Muthuswamy, L, Hudson, T J, Harismendy, O, Barrett, C L, Jamieson, C H M, Carson, D A, Kipps, T J, Frazer, K A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450323/
https://www.ncbi.nlm.nih.gov/pubmed/25860294
http://dx.doi.org/10.1038/bcj.2015.14

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