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The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes
The novel avian origin influenza A (H7N9) virus has caused severe diseases in humans in eastern China since the spring of 2013. Fatal outcomes of H7N9 infections are often attributed to the severe pneumonia and acute respiratory distress syndrome (ARDS). There is urgent need to discover biomarkers p...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450576/ https://www.ncbi.nlm.nih.gov/pubmed/26028236 http://dx.doi.org/10.1038/srep10942 |
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| author | Guo, Jing Huang, Fengming Liu, Jun Chen, Yu Wang, Wei Cao, Bin Zou, Zhen Liu, Song Pan, Jingcao Bao, Changjun Zeng, Mei Xiao, Haixia Gao, Hainv Yang, Shigui Zhao, Yan Liu, Qiang Zhou, Huandi Zhu, Jingdong Liu, Xiaoli Liang, Weifeng Yang, Yida Zheng, Shufa Yang, Jiezuan Diao, Hongyan Su, Kunkai Shao, Li Cao, Hongcui Wu, Ying Zhao, Min Tan, Shuguang Li, Hui Xu, Xiaoqing Wang, Chunmei Zhang, Jianmin Wang, Li Wang, Jianwei Xu, Jun Li, Dangsheng Zhong, Nanshan Cao, Xuetao Gao, George F. Li, Lanjuan Jiang, Chengyu |
| author_facet | Guo, Jing Huang, Fengming Liu, Jun Chen, Yu Wang, Wei Cao, Bin Zou, Zhen Liu, Song Pan, Jingcao Bao, Changjun Zeng, Mei Xiao, Haixia Gao, Hainv Yang, Shigui Zhao, Yan Liu, Qiang Zhou, Huandi Zhu, Jingdong Liu, Xiaoli Liang, Weifeng Yang, Yida Zheng, Shufa Yang, Jiezuan Diao, Hongyan Su, Kunkai Shao, Li Cao, Hongcui Wu, Ying Zhao, Min Tan, Shuguang Li, Hui Xu, Xiaoqing Wang, Chunmei Zhang, Jianmin Wang, Li Wang, Jianwei Xu, Jun Li, Dangsheng Zhong, Nanshan Cao, Xuetao Gao, George F. Li, Lanjuan Jiang, Chengyu |
| author_sort | Guo, Jing |
| collection | PubMed |
| description | The novel avian origin influenza A (H7N9) virus has caused severe diseases in humans in eastern China since the spring of 2013. Fatal outcomes of H7N9 infections are often attributed to the severe pneumonia and acute respiratory distress syndrome (ARDS). There is urgent need to discover biomarkers predicting the progression of disease and fatal outcome of potentially lethal flu infections, based on sound statistical analysis. We discovered that 34 of the 48 cytokines and chemokines examined in this study were significantly elevated in the plasma samples from patients infected with H7N9. We report for the first time that the levels of MIF, SCF, MCP-1, HGF, and SCGF-β are highly positively linked to disease severity and the profile of mediators MIF, SCF, MCP-1, HGF, SCGF-β, IP-10, IL-18, and IFN-γ is an independent outcome predictor. |
| format | Online Article Text |
| id | pubmed-4450576 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-44505762015-06-10 The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes Guo, Jing Huang, Fengming Liu, Jun Chen, Yu Wang, Wei Cao, Bin Zou, Zhen Liu, Song Pan, Jingcao Bao, Changjun Zeng, Mei Xiao, Haixia Gao, Hainv Yang, Shigui Zhao, Yan Liu, Qiang Zhou, Huandi Zhu, Jingdong Liu, Xiaoli Liang, Weifeng Yang, Yida Zheng, Shufa Yang, Jiezuan Diao, Hongyan Su, Kunkai Shao, Li Cao, Hongcui Wu, Ying Zhao, Min Tan, Shuguang Li, Hui Xu, Xiaoqing Wang, Chunmei Zhang, Jianmin Wang, Li Wang, Jianwei Xu, Jun Li, Dangsheng Zhong, Nanshan Cao, Xuetao Gao, George F. Li, Lanjuan Jiang, Chengyu Sci Rep Article The novel avian origin influenza A (H7N9) virus has caused severe diseases in humans in eastern China since the spring of 2013. Fatal outcomes of H7N9 infections are often attributed to the severe pneumonia and acute respiratory distress syndrome (ARDS). There is urgent need to discover biomarkers predicting the progression of disease and fatal outcome of potentially lethal flu infections, based on sound statistical analysis. We discovered that 34 of the 48 cytokines and chemokines examined in this study were significantly elevated in the plasma samples from patients infected with H7N9. We report for the first time that the levels of MIF, SCF, MCP-1, HGF, and SCGF-β are highly positively linked to disease severity and the profile of mediators MIF, SCF, MCP-1, HGF, SCGF-β, IP-10, IL-18, and IFN-γ is an independent outcome predictor. Nature Publishing Group 2015-06-01 /pmc/articles/PMC4450576/ /pubmed/26028236 http://dx.doi.org/10.1038/srep10942 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Guo, Jing Huang, Fengming Liu, Jun Chen, Yu Wang, Wei Cao, Bin Zou, Zhen Liu, Song Pan, Jingcao Bao, Changjun Zeng, Mei Xiao, Haixia Gao, Hainv Yang, Shigui Zhao, Yan Liu, Qiang Zhou, Huandi Zhu, Jingdong Liu, Xiaoli Liang, Weifeng Yang, Yida Zheng, Shufa Yang, Jiezuan Diao, Hongyan Su, Kunkai Shao, Li Cao, Hongcui Wu, Ying Zhao, Min Tan, Shuguang Li, Hui Xu, Xiaoqing Wang, Chunmei Zhang, Jianmin Wang, Li Wang, Jianwei Xu, Jun Li, Dangsheng Zhong, Nanshan Cao, Xuetao Gao, George F. Li, Lanjuan Jiang, Chengyu The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes |
| title | The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes |
| title_full | The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes |
| title_fullStr | The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes |
| title_full_unstemmed | The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes |
| title_short | The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes |
| title_sort | serum profile of hypercytokinemia factors identified in h7n9-infected patients can predict fatal outcomes |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450576/ https://www.ncbi.nlm.nih.gov/pubmed/26028236 http://dx.doi.org/10.1038/srep10942 |
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