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Physical activity and white matter hyperintensities: A systematic review of quantitative studies
OBJECTIVE: White matter hyperintensities (WMH) are markers of brain white matter injury seen on magnetic resonance imaging. WMH increase with age and are associated with neuropsychiatric disorders. WMH progression can be slowed by controlling vascular risk factors in individuals with advanced diseas...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450803/ https://www.ncbi.nlm.nih.gov/pubmed/26046015 http://dx.doi.org/10.1016/j.pmedr.2015.04.013 |
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author | Torres, Elisa R. Strack, Emily F. Fernandez, Claire E. Tumey, Tyler A. Hitchcock, Mary E. |
author_facet | Torres, Elisa R. Strack, Emily F. Fernandez, Claire E. Tumey, Tyler A. Hitchcock, Mary E. |
author_sort | Torres, Elisa R. |
collection | PubMed |
description | OBJECTIVE: White matter hyperintensities (WMH) are markers of brain white matter injury seen on magnetic resonance imaging. WMH increase with age and are associated with neuropsychiatric disorders. WMH progression can be slowed by controlling vascular risk factors in individuals with advanced disease. Since physical activity can decrease vascular risk factors, physical activity may slow the progression of WMH in individuals without advanced disease, thereby preventing neuropsychiatric disorders. The purpose of this systematic review was to examine the association between physical activity and WMH in individuals without advanced disease. METHODS: Articles published in English through March 18, 2014 were searched using PubMed, Web of Science, Cochrane Library and EBSCOhost. RESULTS: Six studies found that more physical activity was associated with less WMH, while 6 found no association. Physical activity is associated with less WMH in individuals without advanced disease when studies are longitudinal or take into consideration physical activity across the lifespan, have a younger sample of older adults, measure different types of physical activity beyond leisure or objectively measure fitness via VO(2) max, measure WMH manually or semi-automatically, and control for risk factors associated with WMH. CONCLUSION: More physical activity was associated with less white matter hyperintensities in individuals without advanced disease. |
format | Online Article Text |
id | pubmed-4450803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-44508032016-01-01 Physical activity and white matter hyperintensities: A systematic review of quantitative studies Torres, Elisa R. Strack, Emily F. Fernandez, Claire E. Tumey, Tyler A. Hitchcock, Mary E. Prev Med Rep Regular Article OBJECTIVE: White matter hyperintensities (WMH) are markers of brain white matter injury seen on magnetic resonance imaging. WMH increase with age and are associated with neuropsychiatric disorders. WMH progression can be slowed by controlling vascular risk factors in individuals with advanced disease. Since physical activity can decrease vascular risk factors, physical activity may slow the progression of WMH in individuals without advanced disease, thereby preventing neuropsychiatric disorders. The purpose of this systematic review was to examine the association between physical activity and WMH in individuals without advanced disease. METHODS: Articles published in English through March 18, 2014 were searched using PubMed, Web of Science, Cochrane Library and EBSCOhost. RESULTS: Six studies found that more physical activity was associated with less WMH, while 6 found no association. Physical activity is associated with less WMH in individuals without advanced disease when studies are longitudinal or take into consideration physical activity across the lifespan, have a younger sample of older adults, measure different types of physical activity beyond leisure or objectively measure fitness via VO(2) max, measure WMH manually or semi-automatically, and control for risk factors associated with WMH. CONCLUSION: More physical activity was associated with less white matter hyperintensities in individuals without advanced disease. Elsevier 2015-04-29 /pmc/articles/PMC4450803/ /pubmed/26046015 http://dx.doi.org/10.1016/j.pmedr.2015.04.013 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Torres, Elisa R. Strack, Emily F. Fernandez, Claire E. Tumey, Tyler A. Hitchcock, Mary E. Physical activity and white matter hyperintensities: A systematic review of quantitative studies |
title | Physical activity and white matter hyperintensities: A systematic review of quantitative studies |
title_full | Physical activity and white matter hyperintensities: A systematic review of quantitative studies |
title_fullStr | Physical activity and white matter hyperintensities: A systematic review of quantitative studies |
title_full_unstemmed | Physical activity and white matter hyperintensities: A systematic review of quantitative studies |
title_short | Physical activity and white matter hyperintensities: A systematic review of quantitative studies |
title_sort | physical activity and white matter hyperintensities: a systematic review of quantitative studies |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450803/ https://www.ncbi.nlm.nih.gov/pubmed/26046015 http://dx.doi.org/10.1016/j.pmedr.2015.04.013 |
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