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Active immunization with Tocilizumab mimotopes induces specific immune responses

BACKGROUND: Tocilizumab is a humanized monoclonal antibody showing high-affinity binding to both soluble interleukin-6 receptor (sIL-6R) and membrane bound IL-6R (mIL-6R), thereby preventing pro-inflammatory effects of IL-6. However, therapeutic antibodies still have practical limitations. To overco...

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Detalles Bibliográficos
Autores principales:	Yang, Lin, Xing, Rui, Li, Changhong, Liu, Yuan, Sun, Lin, Liu, Xiangyuan, Wang, Yongfu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450830/ https://www.ncbi.nlm.nih.gov/pubmed/26033236 http://dx.doi.org/10.1186/s12896-015-0161-9

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