Association between human papillomavirus and Epstein - Barr virus DNA and gene promoter methylation of RB1 and CDH1 in the cervical lesions: a transversal study

BACKGROUND: Human papillomavirus (HPV) inactivates the retinoblastoma 1 (RB1) gene by promoter methylation and reduces cellular E-cadherin expression by overexpression of DNA methyltransferase 1 (DNMT1). The Epstein-Barr virus (EBV) is an oncogenic virus that may be related to cervical carcinogenesi...

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Detalles Bibliográficos
Autores principales: McCormick, Thaís M, Canedo, Nathalie HS, Furtado, Yara L, Silveira, Filomena A, de Lima, Roberto J, Rosman, Andréa DF, Almeida Filho, Gutemberg L, Carvalho, Maria da Glória da C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450846/
https://www.ncbi.nlm.nih.gov/pubmed/26032781
http://dx.doi.org/10.1186/s13000-015-0283-3

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