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Association between human papillomavirus and Epstein - Barr virus DNA and gene promoter methylation of RB1 and CDH1 in the cervical lesions: a transversal study
BACKGROUND: Human papillomavirus (HPV) inactivates the retinoblastoma 1 (RB1) gene by promoter methylation and reduces cellular E-cadherin expression by overexpression of DNA methyltransferase 1 (DNMT1). The Epstein-Barr virus (EBV) is an oncogenic virus that may be related to cervical carcinogenesi...
Autores principales: | McCormick, Thaís M, Canedo, Nathalie HS, Furtado, Yara L, Silveira, Filomena A, de Lima, Roberto J, Rosman, Andréa DF, Almeida Filho, Gutemberg L, Carvalho, Maria da Glória da C |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450846/ https://www.ncbi.nlm.nih.gov/pubmed/26032781 http://dx.doi.org/10.1186/s13000-015-0283-3 |
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