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The fructose tolerance test in patients with chronic kidney disease and metabolic syndrome in comparison to healthy controls
BACKGROUND: Fructose acutely raises serum uric acid in normal subjects, but the effect in subjects with metabolic syndrome or subjects with chronic kidney disease is unknown. The aim of the study was to evaluate changes in serum uric acid during the fructose tolerance test in patients with chronic k...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450852/ https://www.ncbi.nlm.nih.gov/pubmed/25935771 http://dx.doi.org/10.1186/s12882-015-0048-y |
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author | Donderski, Rafał Miśkowiec-Wiśniewska, Ilona Kretowicz, Marek Grajewska, Magdalena Manitius, Jacek Kamińska, Anna Junik, Roman Siódmiak, Joanna Stefańska, Anna Odrowąż-Sypniewska, Grażyna Pluta, Agnieszka Lanaspa, Miguel Johnson, Richard J |
author_facet | Donderski, Rafał Miśkowiec-Wiśniewska, Ilona Kretowicz, Marek Grajewska, Magdalena Manitius, Jacek Kamińska, Anna Junik, Roman Siódmiak, Joanna Stefańska, Anna Odrowąż-Sypniewska, Grażyna Pluta, Agnieszka Lanaspa, Miguel Johnson, Richard J |
author_sort | Donderski, Rafał |
collection | PubMed |
description | BACKGROUND: Fructose acutely raises serum uric acid in normal subjects, but the effect in subjects with metabolic syndrome or subjects with chronic kidney disease is unknown. The aim of the study was to evaluate changes in serum uric acid during the fructose tolerance test in patients with chronic kidney disease, metabolic syndrome with comparison to healthy controls. METHODS: Studies were performed in 36 subjects with obesity (body mass index >30) and metabolic syndrome, 14 patients with stage 3 chronic kidney disease, and 25 healthy volunteers. The fructose tolerance test was performed in each patient. The change in serum uric acid during the fructose challenge was correlated with baseline ambulatory blood pressure, serum uric acid, metabolic, and inflammatory markers, and target organ injury including carotid intima media thickness and renal resistive index (determined by Doppler). RESULTS: Absolute serum uric acid values were highest in the chronic kidney disease group, followed by the metabolic syndrome and then healthy controls. Similar increases in serum uric acid in response to the fructose tolerance test was observed in all three groups, but the greatest percent rise was observed in healthy controls compared to the other two groups. No significant association was shown between the relative rise in uric acid and clinical or inflammatory parameters associated with kidney disease (albuminuria, eGFR) or metabolic syndrome. CONCLUSIONS: Subjects with chronic kidney disease and metabolic syndrome have higher absolute uric acid values following a fructose tolerance test, but show a relatively smaller percent increase in serum uric acid. Changes in serum uric acid during the fructose tolerance test did not correlate with changes in metabolic parameters, inflammatory mediators or with target organ injury. These studies suggest that acute changes in serum uric acid in response to fructose do not predict the metabolic phenotype or presence of inflammatory mediators in subjects with obesity, metabolic syndrome or chronic kidney disease. TRIAL REGISTRATION: The study was registered in ClinicalTrials.gov. Identifier : NCT01332526. www.register.clinicaltrials.gov/01332526 ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12882-015-0048-y) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4450852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44508522015-06-02 The fructose tolerance test in patients with chronic kidney disease and metabolic syndrome in comparison to healthy controls Donderski, Rafał Miśkowiec-Wiśniewska, Ilona Kretowicz, Marek Grajewska, Magdalena Manitius, Jacek Kamińska, Anna Junik, Roman Siódmiak, Joanna Stefańska, Anna Odrowąż-Sypniewska, Grażyna Pluta, Agnieszka Lanaspa, Miguel Johnson, Richard J BMC Nephrol Research Article BACKGROUND: Fructose acutely raises serum uric acid in normal subjects, but the effect in subjects with metabolic syndrome or subjects with chronic kidney disease is unknown. The aim of the study was to evaluate changes in serum uric acid during the fructose tolerance test in patients with chronic kidney disease, metabolic syndrome with comparison to healthy controls. METHODS: Studies were performed in 36 subjects with obesity (body mass index >30) and metabolic syndrome, 14 patients with stage 3 chronic kidney disease, and 25 healthy volunteers. The fructose tolerance test was performed in each patient. The change in serum uric acid during the fructose challenge was correlated with baseline ambulatory blood pressure, serum uric acid, metabolic, and inflammatory markers, and target organ injury including carotid intima media thickness and renal resistive index (determined by Doppler). RESULTS: Absolute serum uric acid values were highest in the chronic kidney disease group, followed by the metabolic syndrome and then healthy controls. Similar increases in serum uric acid in response to the fructose tolerance test was observed in all three groups, but the greatest percent rise was observed in healthy controls compared to the other two groups. No significant association was shown between the relative rise in uric acid and clinical or inflammatory parameters associated with kidney disease (albuminuria, eGFR) or metabolic syndrome. CONCLUSIONS: Subjects with chronic kidney disease and metabolic syndrome have higher absolute uric acid values following a fructose tolerance test, but show a relatively smaller percent increase in serum uric acid. Changes in serum uric acid during the fructose tolerance test did not correlate with changes in metabolic parameters, inflammatory mediators or with target organ injury. These studies suggest that acute changes in serum uric acid in response to fructose do not predict the metabolic phenotype or presence of inflammatory mediators in subjects with obesity, metabolic syndrome or chronic kidney disease. TRIAL REGISTRATION: The study was registered in ClinicalTrials.gov. Identifier : NCT01332526. www.register.clinicaltrials.gov/01332526 ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12882-015-0048-y) contains supplementary material, which is available to authorized users. BioMed Central 2015-05-03 /pmc/articles/PMC4450852/ /pubmed/25935771 http://dx.doi.org/10.1186/s12882-015-0048-y Text en © Donderski et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Donderski, Rafał Miśkowiec-Wiśniewska, Ilona Kretowicz, Marek Grajewska, Magdalena Manitius, Jacek Kamińska, Anna Junik, Roman Siódmiak, Joanna Stefańska, Anna Odrowąż-Sypniewska, Grażyna Pluta, Agnieszka Lanaspa, Miguel Johnson, Richard J The fructose tolerance test in patients with chronic kidney disease and metabolic syndrome in comparison to healthy controls |
title | The fructose tolerance test in patients with chronic kidney disease and metabolic syndrome in comparison to healthy controls |
title_full | The fructose tolerance test in patients with chronic kidney disease and metabolic syndrome in comparison to healthy controls |
title_fullStr | The fructose tolerance test in patients with chronic kidney disease and metabolic syndrome in comparison to healthy controls |
title_full_unstemmed | The fructose tolerance test in patients with chronic kidney disease and metabolic syndrome in comparison to healthy controls |
title_short | The fructose tolerance test in patients with chronic kidney disease and metabolic syndrome in comparison to healthy controls |
title_sort | fructose tolerance test in patients with chronic kidney disease and metabolic syndrome in comparison to healthy controls |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450852/ https://www.ncbi.nlm.nih.gov/pubmed/25935771 http://dx.doi.org/10.1186/s12882-015-0048-y |
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