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Perirhinal Cortex Lesions in Rats: Novelty Detection and Sensitivity to Interference

Rats with perirhinal cortex lesions received multiple object recognition trials within a continuous session to examine whether they show false memories. Experiment 1 focused on exploration patterns during the first object recognition test postsurgery, in which each trial contained 1 novel and 1 fami...

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Autores principales: Albasser, Mathieu M., Olarte-Sánchez, Cristian M., Amin, Eman, Brown, Malcolm W., Kinnavane, Lisa, Aggleton, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Psychological Association 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450885/
https://www.ncbi.nlm.nih.gov/pubmed/26030425
http://dx.doi.org/10.1037/bne0000049
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author Albasser, Mathieu M.
Olarte-Sánchez, Cristian M.
Amin, Eman
Brown, Malcolm W.
Kinnavane, Lisa
Aggleton, John P.
author_facet Albasser, Mathieu M.
Olarte-Sánchez, Cristian M.
Amin, Eman
Brown, Malcolm W.
Kinnavane, Lisa
Aggleton, John P.
author_sort Albasser, Mathieu M.
collection PubMed
description Rats with perirhinal cortex lesions received multiple object recognition trials within a continuous session to examine whether they show false memories. Experiment 1 focused on exploration patterns during the first object recognition test postsurgery, in which each trial contained 1 novel and 1 familiar object. The perirhinal cortex lesions reduced time spent exploring novel objects, but did not affect overall time spent exploring the test objects (novel plus familiar). Replications with subsequent cohorts of rats (Experiments 2, 3, 4.1) repeated this pattern of results. When all recognition memory data were combined (Experiments 1–4), giving totals of 44 perirhinal lesion rats and 40 surgical sham controls, the perirhinal cortex lesions caused a marginal reduction in total exploration time. That decrease in time with novel objects was often compensated by increased exploration of familiar objects. Experiment 4 also assessed the impact of proactive interference on recognition memory. Evidence emerged that prior object experience could additionally impair recognition performance in rats with perirhinal cortex lesions. Experiment 5 examined exploration levels when rats were just given pairs of novel objects to explore. Despite their perirhinal cortex lesions, exploration levels were comparable with those of control rats. While the results of Experiment 4 support the notion that perirhinal lesions can increase sensitivity to proactive interference, the overall findings question whether rats lacking a perirhinal cortex typically behave as if novel objects are familiar, that is, show false recognition. Rather, the rats retain a signal of novelty but struggle to discriminate the identity of that signal.
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spelling pubmed-44508852015-06-11 Perirhinal Cortex Lesions in Rats: Novelty Detection and Sensitivity to Interference Albasser, Mathieu M. Olarte-Sánchez, Cristian M. Amin, Eman Brown, Malcolm W. Kinnavane, Lisa Aggleton, John P. Behav Neurosci Articles Rats with perirhinal cortex lesions received multiple object recognition trials within a continuous session to examine whether they show false memories. Experiment 1 focused on exploration patterns during the first object recognition test postsurgery, in which each trial contained 1 novel and 1 familiar object. The perirhinal cortex lesions reduced time spent exploring novel objects, but did not affect overall time spent exploring the test objects (novel plus familiar). Replications with subsequent cohorts of rats (Experiments 2, 3, 4.1) repeated this pattern of results. When all recognition memory data were combined (Experiments 1–4), giving totals of 44 perirhinal lesion rats and 40 surgical sham controls, the perirhinal cortex lesions caused a marginal reduction in total exploration time. That decrease in time with novel objects was often compensated by increased exploration of familiar objects. Experiment 4 also assessed the impact of proactive interference on recognition memory. Evidence emerged that prior object experience could additionally impair recognition performance in rats with perirhinal cortex lesions. Experiment 5 examined exploration levels when rats were just given pairs of novel objects to explore. Despite their perirhinal cortex lesions, exploration levels were comparable with those of control rats. While the results of Experiment 4 support the notion that perirhinal lesions can increase sensitivity to proactive interference, the overall findings question whether rats lacking a perirhinal cortex typically behave as if novel objects are familiar, that is, show false recognition. Rather, the rats retain a signal of novelty but struggle to discriminate the identity of that signal. American Psychological Association 2015-06 /pmc/articles/PMC4450885/ /pubmed/26030425 http://dx.doi.org/10.1037/bne0000049 Text en © 2015 The Author(s) http://creativecommons.org/licenses/by/3.0/ This article has been published under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s). Author(s) grant(s) the American Psychological Association the exclusive right to publish the article and identify itself as the original publisher.
spellingShingle Articles
Albasser, Mathieu M.
Olarte-Sánchez, Cristian M.
Amin, Eman
Brown, Malcolm W.
Kinnavane, Lisa
Aggleton, John P.
Perirhinal Cortex Lesions in Rats: Novelty Detection and Sensitivity to Interference
title Perirhinal Cortex Lesions in Rats: Novelty Detection and Sensitivity to Interference
title_full Perirhinal Cortex Lesions in Rats: Novelty Detection and Sensitivity to Interference
title_fullStr Perirhinal Cortex Lesions in Rats: Novelty Detection and Sensitivity to Interference
title_full_unstemmed Perirhinal Cortex Lesions in Rats: Novelty Detection and Sensitivity to Interference
title_short Perirhinal Cortex Lesions in Rats: Novelty Detection and Sensitivity to Interference
title_sort perirhinal cortex lesions in rats: novelty detection and sensitivity to interference
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450885/
https://www.ncbi.nlm.nih.gov/pubmed/26030425
http://dx.doi.org/10.1037/bne0000049
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