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Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations

T cells modified with chimeric antigen receptors (CARs) targeting CD19 demonstrated clinical activity against some B-cell malignancies. However, this is often accompanied by a loss of normal CD19(+) B cells and humoral immunity. Receptor tyrosine kinase-like orphan receptor-1 (ROR1) is expressed on...

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Detalles Bibliográficos
Autores principales:	Deniger, Drew C., Yu, Jianqiang, Huls, M. Helen, Figliola, Matthew J., Mi, Tiejuan, Maiti, Sourindra N., Widhopf, George F., Hurton, Lenka V., Thokala, Radhika, Singh, Harjeet, Olivares, Simon, Champlin, Richard E., Wierda, William G., Kipps, Thomas J., Cooper, Laurence J. N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451012/ https://www.ncbi.nlm.nih.gov/pubmed/26030772 http://dx.doi.org/10.1371/journal.pone.0128151

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