Replication of Plasmodium in reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance

Most studies on malaria-parasite digestion of hemoglobin (Hb) have been performed using P. falciparum maintained in mature erythrocytes, in vitro. In this study, we examine Plasmodium Hb degradation in vivo in mice, using the parasite P. berghei, and show that it is possible to create mutant parasit...

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Detalles Bibliográficos
Autores principales: Lin, Jing-wen, Spaccapelo, Roberta, Schwarzer, Evelin, Sajid, Mohammed, Annoura, Takeshi, Deroost, Katrien, Ravelli, Raimond B.G., Aime, Elena, Capuccini, Barbara, Mommaas-Kienhuis, Anna M., O’Toole, Tom, Prins, Frans, Franke-Fayard, Blandine M.D., Ramesar, Jai, Chevalley-Maurel, Séverine, Kroeze, Hans, Koster, Abraham J., Tanke, Hans J., Crisanti, Andrea, Langhorne, Jean, Arese, Paolo, Van den Steen, Philippe E., Janse, Chris J., Khan, Shahid M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451122/
https://www.ncbi.nlm.nih.gov/pubmed/25941254
http://dx.doi.org/10.1084/jem.20141731

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