An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode

Pentraxin 3 (PTX3) is a fluid-phase pattern recognition molecule and a key component of the humoral arm of innate immunity. In four different models of tissue damage in mice, PTX3 deficiency was associated with increased fibrin deposition and persistence, and thicker clots, followed by increased col...

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Detalles Bibliográficos
Autores principales: Doni, Andrea, Musso, Tiziana, Morone, Diego, Bastone, Antonio, Zambelli, Vanessa, Sironi, Marina, Castagnoli, Carlotta, Cambieri, Irene, Stravalaci, Matteo, Pasqualini, Fabio, Laface, Ilaria, Valentino, Sonia, Tartari, Silvia, Ponzetta, Andrea, Maina, Virginia, Barbieri, Silvia S., Tremoli, Elena, Catapano, Alberico L., Norata, Giuseppe D., Bottazzi, Barbara, Garlanda, Cecilia, Mantovani, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451130/
https://www.ncbi.nlm.nih.gov/pubmed/25964372
http://dx.doi.org/10.1084/jem.20141268

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