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Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice

The widely recognized neuroprotective effect of iron chelators is contributed by their ability to prevent reactive oxygen species (ROS) generation via the Fenton reaction, which sequesters redox-active Fe. An additional neuroprotective mechanism of iron-chelating compounds is to regulate the transcr...

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Detalles Bibliográficos
Autores principales:	Guo, Chuang, Zhang, Yu-Xin, Wang, Tao, Zhong, Man-Li, Yang, Zhao-Hui, Hao, Li-Juan, Chai, Rui, Zhang, Shuai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451419/ https://www.ncbi.nlm.nih.gov/pubmed/26082716 http://dx.doi.org/10.3389/fnagi.2015.00104

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