USP7 modulates UV-induced PCNA monoubiquitination by regulating DNA polymerase eta stability

DNA polymerase eta (Polη) plays unique and pivotal functions in several DNA damage-tolerance pathways. Steady-state level of this short-lived protein is tightly controlled by multiple mechanisms including proteolysis. Here, we have identified the deubiquitinating enzyme, ubiquitin-specific protease...

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Detalles Bibliográficos
Autores principales: Qian, Jiang, Pentz, Kyle, Zhu, Qianzheng, Wang, Qien, He, Jinshan, Srivastava, Amit K., Wani, Altaf A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451444/
https://www.ncbi.nlm.nih.gov/pubmed/25435364
http://dx.doi.org/10.1038/onc.2014.394

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