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The Response of Greek Key Proteins to Changes in Connectivity Depends on the Nature of Their Secondary Structure
What governs the balance between connectivity and topology in regulating the mechanism of protein folding? We use circular permutation to vary the order of the helices in the all-α Greek key protein FADD (Fas-associated death domain) to investigate this question. Unlike all-β Greek key proteins, whe...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451459/ https://www.ncbi.nlm.nih.gov/pubmed/25861761 http://dx.doi.org/10.1016/j.jmb.2015.03.020 |