Structure of a Single-Chain Fv Bound to the 17 N-Terminal Residues of Huntingtin Provides Insights into Pathogenic Amyloid Formation and Suppression

Huntington's disease is triggered by misfolding of fragments of mutant forms of the huntingtin protein (mHTT) with aberrant polyglutamine expansions. The C4 single-chain Fv antibody (scFv) binds to the first 17 residues of huntingtin [HTT(1-17)] and generates substantial protection against mult...

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Detalles Bibliográficos
Autores principales: De Genst, Erwin, Chirgadze, Dimitri Y., Klein, Fabrice A.C., Butler, David C., Matak-Vinković, Dijana, Trottier, Yvon, Huston, James S., Messer, Anne, Dobson, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451460/
https://www.ncbi.nlm.nih.gov/pubmed/25861763
http://dx.doi.org/10.1016/j.jmb.2015.03.021

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