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Sleep influences the intracerebral EEG pattern of focal cortical dysplasia

OBJECTIVE: Focal cortical dysplasia (FCD) is able to generate an intrinsic pathological EEG activity characterized by a continuous or near-continuous spiking. Different patterns of discharge were described. We examined quantitatively the distribution of the intracerebral FCD patterns in relation to...

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Autores principales: Menezes Cordeiro, Inês, von Ellenrieder, Nicolas, Zazubovits, Natalja, Dubeau, François, Gotman, Jean, Frauscher, Birgit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Publishers 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451468/
https://www.ncbi.nlm.nih.gov/pubmed/25986200
http://dx.doi.org/10.1016/j.eplepsyres.2015.03.014
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author Menezes Cordeiro, Inês
von Ellenrieder, Nicolas
Zazubovits, Natalja
Dubeau, François
Gotman, Jean
Frauscher, Birgit
author_facet Menezes Cordeiro, Inês
von Ellenrieder, Nicolas
Zazubovits, Natalja
Dubeau, François
Gotman, Jean
Frauscher, Birgit
author_sort Menezes Cordeiro, Inês
collection PubMed
description OBJECTIVE: Focal cortical dysplasia (FCD) is able to generate an intrinsic pathological EEG activity characterized by a continuous or near-continuous spiking. Different patterns of discharge were described. We examined quantitatively the distribution of the intracerebral FCD patterns in relation to sleep in order to investigate whether this activity is independent of thalamocortical influences. METHODS: We analyzed the first sleep cycle of 5 patients with a diagnosis of FCD type II who underwent combined scalp-intracranial electroencephalography (EEG), and showed an intracranial EEG pattern typical for FCD. Three patterns of FCD intracranial EEG activity were identified in all 5 patients, and visually marked for a maximum of 30 min of each stage (wake, N1, N2, N3, REM): spike or polyspike exceeding 2 Hz (pattern 1), spike or polyspike interrupted by flat periods below 2 Hz (pattern 2) and discharges of >15 Hz low-voltage rhythmic activity with regular morphology (pattern 3). After marking, the percentages of the three patterns across the different stages were calculated. RESULTS: The three patterns of FCD were present between 45% and 97% of the total time analyzed. Pattern 1 was the predominant pattern in wakefulness (73–100%), N1 (76–97%) and N2 (58–88.5%) in all patients, and in REM in 4 of 5 patients (91–100%). During N2 and N3, there was an increase in pattern 2 in all patients, becoming the predominant pattern in 3 of the 5 patients during N3 (63–89%). Pattern 3 was rare and only sporadically observed during N2 and N3. Wakefulness and REM sleep showed a similar pattern (pattern 1) with a slight amplitude reduction in REM sleep. SIGNIFICANCE: Despite the presence of an almost continuous discharge, sleep is an important modulator of the pathological EEG patterns found in FCD type II. This might suggest that dysplastic tissue is influenced by the thalamo-cortical control mechanisms involved in the generation of sleep.
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spelling pubmed-44514682015-07-01 Sleep influences the intracerebral EEG pattern of focal cortical dysplasia Menezes Cordeiro, Inês von Ellenrieder, Nicolas Zazubovits, Natalja Dubeau, François Gotman, Jean Frauscher, Birgit Epilepsy Res Article OBJECTIVE: Focal cortical dysplasia (FCD) is able to generate an intrinsic pathological EEG activity characterized by a continuous or near-continuous spiking. Different patterns of discharge were described. We examined quantitatively the distribution of the intracerebral FCD patterns in relation to sleep in order to investigate whether this activity is independent of thalamocortical influences. METHODS: We analyzed the first sleep cycle of 5 patients with a diagnosis of FCD type II who underwent combined scalp-intracranial electroencephalography (EEG), and showed an intracranial EEG pattern typical for FCD. Three patterns of FCD intracranial EEG activity were identified in all 5 patients, and visually marked for a maximum of 30 min of each stage (wake, N1, N2, N3, REM): spike or polyspike exceeding 2 Hz (pattern 1), spike or polyspike interrupted by flat periods below 2 Hz (pattern 2) and discharges of >15 Hz low-voltage rhythmic activity with regular morphology (pattern 3). After marking, the percentages of the three patterns across the different stages were calculated. RESULTS: The three patterns of FCD were present between 45% and 97% of the total time analyzed. Pattern 1 was the predominant pattern in wakefulness (73–100%), N1 (76–97%) and N2 (58–88.5%) in all patients, and in REM in 4 of 5 patients (91–100%). During N2 and N3, there was an increase in pattern 2 in all patients, becoming the predominant pattern in 3 of the 5 patients during N3 (63–89%). Pattern 3 was rare and only sporadically observed during N2 and N3. Wakefulness and REM sleep showed a similar pattern (pattern 1) with a slight amplitude reduction in REM sleep. SIGNIFICANCE: Despite the presence of an almost continuous discharge, sleep is an important modulator of the pathological EEG patterns found in FCD type II. This might suggest that dysplastic tissue is influenced by the thalamo-cortical control mechanisms involved in the generation of sleep. Elsevier Science Publishers 2015-07 /pmc/articles/PMC4451468/ /pubmed/25986200 http://dx.doi.org/10.1016/j.eplepsyres.2015.03.014 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Menezes Cordeiro, Inês
von Ellenrieder, Nicolas
Zazubovits, Natalja
Dubeau, François
Gotman, Jean
Frauscher, Birgit
Sleep influences the intracerebral EEG pattern of focal cortical dysplasia
title Sleep influences the intracerebral EEG pattern of focal cortical dysplasia
title_full Sleep influences the intracerebral EEG pattern of focal cortical dysplasia
title_fullStr Sleep influences the intracerebral EEG pattern of focal cortical dysplasia
title_full_unstemmed Sleep influences the intracerebral EEG pattern of focal cortical dysplasia
title_short Sleep influences the intracerebral EEG pattern of focal cortical dysplasia
title_sort sleep influences the intracerebral eeg pattern of focal cortical dysplasia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451468/
https://www.ncbi.nlm.nih.gov/pubmed/25986200
http://dx.doi.org/10.1016/j.eplepsyres.2015.03.014
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