Free Energy Landscape and Multiple Folding Pathways of an H-Type RNA Pseudoknot

How RNA sequences fold to specific tertiary structures is one of the key problems for understanding their dynamics and functions. Here, we study the folding process of an H-type RNA pseudoknot by performing a large-scale all-atom MD simulation and bias-exchange metadynamics. The folding free energy...

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Detalles Bibliográficos
Autores principales: Bian, Yunqiang, Zhang, Jian, Wang, Jun, Wang, Jihua, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451515/
https://www.ncbi.nlm.nih.gov/pubmed/26030098
http://dx.doi.org/10.1371/journal.pone.0129089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451515/
https://www.ncbi.nlm.nih.gov/pubmed/26030098
http://dx.doi.org/10.1371/journal.pone.0129089

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