Cargando…

The master switch: Comparative study of mast cell in oral epithelial dysplasia, oral submucous fibrosis and oral squamous cells carcinoma and their association with inflammation and angiogenesis

BACKGROUND: Dental and medical practitioners encounter wide spectrum of oral lesions in their day-to-day practice. Many of the lesions such as leukoplakia, oral submucous fibrosis (OSF), etc., are associated with tobacco and betel nut chewing. Oral leukoplakia, OSF, oral lichen planus and oral squam...

Descripción completa

Detalles Bibliográficos
Autores principales: Telagi, Neethu, Ahmed Mujib, BR, Kulkarni, Pavan G, Naik, Rashmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451661/
https://www.ncbi.nlm.nih.gov/pubmed/26097302
http://dx.doi.org/10.4103/0973-029X.157196
_version_ 1782374170270629888
author Telagi, Neethu
Ahmed Mujib, BR
Kulkarni, Pavan G
Naik, Rashmi
author_facet Telagi, Neethu
Ahmed Mujib, BR
Kulkarni, Pavan G
Naik, Rashmi
author_sort Telagi, Neethu
collection PubMed
description BACKGROUND: Dental and medical practitioners encounter wide spectrum of oral lesions in their day-to-day practice. Many of the lesions such as leukoplakia, oral submucous fibrosis (OSF), etc., are associated with tobacco and betel nut chewing. Oral leukoplakia, OSF, oral lichen planus and oral squamous cell carcinoma (OSCC) are the most commonly occurring oral diseases associated with characteristic clinical and histological features and are associated with chronic inflammation at some stage of the disease process. AIMS: To study and compare the number, morphology and topographical distribution of mast cells in oral epithelial dysplasia (OED), OSF and OSCC and to correlate different types of mast cells with the inflammatory infiltrate and vascularity of the lesions. MATERIALS AND METHODS: Total number of subjects was 120 and equally divided into four groups of 30 as controls, OED, OSF and OSCC cases. Two sections of from each tissue embedded in paraffin wax block were made which were stained with hematoxylin and eosin and toluidine blue stain. Mast cells were counted in five different zones. RESULTS: In the present study, increased numbers of mast cells were seen in all lesions. The cases with mild, moderate and severe inflammation showed increased number of typical (TMCs), atypical (AMCs) and granular mast cells (GMCs), respectively. CONCLUSION: The result of the present study concludes that the mast cells play a key role in mediating the cross links between external angiogenic agent and local immunologic factors.
format Online
Article
Text
id pubmed-4451661
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-44516612015-06-19 The master switch: Comparative study of mast cell in oral epithelial dysplasia, oral submucous fibrosis and oral squamous cells carcinoma and their association with inflammation and angiogenesis Telagi, Neethu Ahmed Mujib, BR Kulkarni, Pavan G Naik, Rashmi J Oral Maxillofac Pathol Original Article BACKGROUND: Dental and medical practitioners encounter wide spectrum of oral lesions in their day-to-day practice. Many of the lesions such as leukoplakia, oral submucous fibrosis (OSF), etc., are associated with tobacco and betel nut chewing. Oral leukoplakia, OSF, oral lichen planus and oral squamous cell carcinoma (OSCC) are the most commonly occurring oral diseases associated with characteristic clinical and histological features and are associated with chronic inflammation at some stage of the disease process. AIMS: To study and compare the number, morphology and topographical distribution of mast cells in oral epithelial dysplasia (OED), OSF and OSCC and to correlate different types of mast cells with the inflammatory infiltrate and vascularity of the lesions. MATERIALS AND METHODS: Total number of subjects was 120 and equally divided into four groups of 30 as controls, OED, OSF and OSCC cases. Two sections of from each tissue embedded in paraffin wax block were made which were stained with hematoxylin and eosin and toluidine blue stain. Mast cells were counted in five different zones. RESULTS: In the present study, increased numbers of mast cells were seen in all lesions. The cases with mild, moderate and severe inflammation showed increased number of typical (TMCs), atypical (AMCs) and granular mast cells (GMCs), respectively. CONCLUSION: The result of the present study concludes that the mast cells play a key role in mediating the cross links between external angiogenic agent and local immunologic factors. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4451661/ /pubmed/26097302 http://dx.doi.org/10.4103/0973-029X.157196 Text en Copyright: © Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Telagi, Neethu
Ahmed Mujib, BR
Kulkarni, Pavan G
Naik, Rashmi
The master switch: Comparative study of mast cell in oral epithelial dysplasia, oral submucous fibrosis and oral squamous cells carcinoma and their association with inflammation and angiogenesis
title The master switch: Comparative study of mast cell in oral epithelial dysplasia, oral submucous fibrosis and oral squamous cells carcinoma and their association with inflammation and angiogenesis
title_full The master switch: Comparative study of mast cell in oral epithelial dysplasia, oral submucous fibrosis and oral squamous cells carcinoma and their association with inflammation and angiogenesis
title_fullStr The master switch: Comparative study of mast cell in oral epithelial dysplasia, oral submucous fibrosis and oral squamous cells carcinoma and their association with inflammation and angiogenesis
title_full_unstemmed The master switch: Comparative study of mast cell in oral epithelial dysplasia, oral submucous fibrosis and oral squamous cells carcinoma and their association with inflammation and angiogenesis
title_short The master switch: Comparative study of mast cell in oral epithelial dysplasia, oral submucous fibrosis and oral squamous cells carcinoma and their association with inflammation and angiogenesis
title_sort master switch: comparative study of mast cell in oral epithelial dysplasia, oral submucous fibrosis and oral squamous cells carcinoma and their association with inflammation and angiogenesis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451661/
https://www.ncbi.nlm.nih.gov/pubmed/26097302
http://dx.doi.org/10.4103/0973-029X.157196
work_keys_str_mv AT telagineethu themasterswitchcomparativestudyofmastcellinoralepithelialdysplasiaoralsubmucousfibrosisandoralsquamouscellscarcinomaandtheirassociationwithinflammationandangiogenesis
AT ahmedmujibbr themasterswitchcomparativestudyofmastcellinoralepithelialdysplasiaoralsubmucousfibrosisandoralsquamouscellscarcinomaandtheirassociationwithinflammationandangiogenesis
AT kulkarnipavang themasterswitchcomparativestudyofmastcellinoralepithelialdysplasiaoralsubmucousfibrosisandoralsquamouscellscarcinomaandtheirassociationwithinflammationandangiogenesis
AT naikrashmi themasterswitchcomparativestudyofmastcellinoralepithelialdysplasiaoralsubmucousfibrosisandoralsquamouscellscarcinomaandtheirassociationwithinflammationandangiogenesis
AT telagineethu masterswitchcomparativestudyofmastcellinoralepithelialdysplasiaoralsubmucousfibrosisandoralsquamouscellscarcinomaandtheirassociationwithinflammationandangiogenesis
AT ahmedmujibbr masterswitchcomparativestudyofmastcellinoralepithelialdysplasiaoralsubmucousfibrosisandoralsquamouscellscarcinomaandtheirassociationwithinflammationandangiogenesis
AT kulkarnipavang masterswitchcomparativestudyofmastcellinoralepithelialdysplasiaoralsubmucousfibrosisandoralsquamouscellscarcinomaandtheirassociationwithinflammationandangiogenesis
AT naikrashmi masterswitchcomparativestudyofmastcellinoralepithelialdysplasiaoralsubmucousfibrosisandoralsquamouscellscarcinomaandtheirassociationwithinflammationandangiogenesis