Both Hepatic and Body Iron Stores Are Increased in Dysmetabolic Iron Overload Syndrome. A Case-Control Study

BACKGROUND & AIMS: Hepatic iron is increased in dysmetabolic iron overload syndrome (DIOS). Whether this reflects elevated body iron stores is still debated. The study was aimed at assessing body iron stores in DIOS patients by calculating the amount of mobilized iron (AMI). METHODS: We conducte...

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Autores principales: Jézéquel, Caroline, Lainé, Fabrice, Laviolle, Bruno, Kiani, Anita, Bardou-Jacquet, Edouard, Deugnier, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451770/
https://www.ncbi.nlm.nih.gov/pubmed/26030828
http://dx.doi.org/10.1371/journal.pone.0128530
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author Jézéquel, Caroline
Lainé, Fabrice
Laviolle, Bruno
Kiani, Anita
Bardou-Jacquet, Edouard
Deugnier, Yves
author_facet Jézéquel, Caroline
Lainé, Fabrice
Laviolle, Bruno
Kiani, Anita
Bardou-Jacquet, Edouard
Deugnier, Yves
author_sort Jézéquel, Caroline
collection PubMed
description BACKGROUND & AIMS: Hepatic iron is increased in dysmetabolic iron overload syndrome (DIOS). Whether this reflects elevated body iron stores is still debated. The study was aimed at assessing body iron stores in DIOS patients by calculating the amount of mobilized iron (AMI). METHODS: We conducted a prospective case-control study comparing AMI in 12 DIOS patients and 12 overweight normoferritinemic subjects matched on BMI and age. All participants were phlebotomized until serum ferritin dropped ≤ 50μg/L. RESULTS: The two groups were comparable with respect to metabolic abnormalities and differed according to serum ferritin levels only. AMI was significantly (p<0.0001) higher in DIOS (2.5g±0.7) than in controls (0.8g±0.3). No side effects were related to phlebotomies.
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spelling pubmed-44517702015-06-09 Both Hepatic and Body Iron Stores Are Increased in Dysmetabolic Iron Overload Syndrome. A Case-Control Study Jézéquel, Caroline Lainé, Fabrice Laviolle, Bruno Kiani, Anita Bardou-Jacquet, Edouard Deugnier, Yves PLoS One Research Article BACKGROUND & AIMS: Hepatic iron is increased in dysmetabolic iron overload syndrome (DIOS). Whether this reflects elevated body iron stores is still debated. The study was aimed at assessing body iron stores in DIOS patients by calculating the amount of mobilized iron (AMI). METHODS: We conducted a prospective case-control study comparing AMI in 12 DIOS patients and 12 overweight normoferritinemic subjects matched on BMI and age. All participants were phlebotomized until serum ferritin dropped ≤ 50μg/L. RESULTS: The two groups were comparable with respect to metabolic abnormalities and differed according to serum ferritin levels only. AMI was significantly (p<0.0001) higher in DIOS (2.5g±0.7) than in controls (0.8g±0.3). No side effects were related to phlebotomies. Public Library of Science 2015-06-01 /pmc/articles/PMC4451770/ /pubmed/26030828 http://dx.doi.org/10.1371/journal.pone.0128530 Text en © 2015 Jézéquel et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Jézéquel, Caroline
Lainé, Fabrice
Laviolle, Bruno
Kiani, Anita
Bardou-Jacquet, Edouard
Deugnier, Yves
Both Hepatic and Body Iron Stores Are Increased in Dysmetabolic Iron Overload Syndrome. A Case-Control Study
title Both Hepatic and Body Iron Stores Are Increased in Dysmetabolic Iron Overload Syndrome. A Case-Control Study
title_full Both Hepatic and Body Iron Stores Are Increased in Dysmetabolic Iron Overload Syndrome. A Case-Control Study
title_fullStr Both Hepatic and Body Iron Stores Are Increased in Dysmetabolic Iron Overload Syndrome. A Case-Control Study
title_full_unstemmed Both Hepatic and Body Iron Stores Are Increased in Dysmetabolic Iron Overload Syndrome. A Case-Control Study
title_short Both Hepatic and Body Iron Stores Are Increased in Dysmetabolic Iron Overload Syndrome. A Case-Control Study
title_sort both hepatic and body iron stores are increased in dysmetabolic iron overload syndrome. a case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451770/
https://www.ncbi.nlm.nih.gov/pubmed/26030828
http://dx.doi.org/10.1371/journal.pone.0128530
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