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Treated Autoimmune Thyroid Disease Is Associated with a Decreased Quality of Life among Young Persons with Type 1 Diabetes
Type 1 diabetes (T1D) in children and adolescents is relatively often accompanied by other immunopathological diseases, autoimmune thyroid disease (AITD) or celiac disease (CD). Our aim was to assess whether these conditions are associated with changes in the health-related quality of life (HRQOL) i...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451782/ https://www.ncbi.nlm.nih.gov/pubmed/26089877 http://dx.doi.org/10.1155/2015/185859 |
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author | Spirkova, Alena Dusatkova, Petra Peckova, Monika Kolouskova, Stanislava Snajderova, Marta Obermannova, Barbora Stechova, Katerina Hrachovinova, Tamara Mares, Jiri Cinek, Ondrej Lebl, Jan Sumnik, Zdenek Pruhova, Stepanka |
author_facet | Spirkova, Alena Dusatkova, Petra Peckova, Monika Kolouskova, Stanislava Snajderova, Marta Obermannova, Barbora Stechova, Katerina Hrachovinova, Tamara Mares, Jiri Cinek, Ondrej Lebl, Jan Sumnik, Zdenek Pruhova, Stepanka |
author_sort | Spirkova, Alena |
collection | PubMed |
description | Type 1 diabetes (T1D) in children and adolescents is relatively often accompanied by other immunopathological diseases, autoimmune thyroid disease (AITD) or celiac disease (CD). Our aim was to assess whether these conditions are associated with changes in the health-related quality of life (HRQOL) in pediatric patients with T1D. In a cross-sectional study we identified eligible 332 patients with T1D aged 8–18 years, of whom 248 (75%) together with their parents responded to the PedsQL Generic and Diabetes Modules. Compared to 143 patients without thyroid autoantibodies, 40 patients with a thyroxine-treated AITD scored lower in the overall generic HRQOL (P = 0.014), as well as in the overall diabetes-specific HRQOL (P = 0.013). After adjustment for age, gender, duration of diabetes, type of diabetes treatment, and diabetes control, this association remained statistically significant for the generic HRQOL (P = 0.023). Celiac disease was not associated with a change in the generic or diabetes-specific HRQOL (P = 0.07 and P = 0.63, resp.). Parental scores showed no association with AITD or celiac disease, except a marginally significant decrease in the overall generic HRQOL (P = 0.039) in the T1D + AITD compared to T1D group. Our study indicates that, in pediatric patients with T1D, concomitant thyroxine-treated AITD is associated with lower quality of life. |
format | Online Article Text |
id | pubmed-4451782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44517822015-06-18 Treated Autoimmune Thyroid Disease Is Associated with a Decreased Quality of Life among Young Persons with Type 1 Diabetes Spirkova, Alena Dusatkova, Petra Peckova, Monika Kolouskova, Stanislava Snajderova, Marta Obermannova, Barbora Stechova, Katerina Hrachovinova, Tamara Mares, Jiri Cinek, Ondrej Lebl, Jan Sumnik, Zdenek Pruhova, Stepanka Int J Endocrinol Research Article Type 1 diabetes (T1D) in children and adolescents is relatively often accompanied by other immunopathological diseases, autoimmune thyroid disease (AITD) or celiac disease (CD). Our aim was to assess whether these conditions are associated with changes in the health-related quality of life (HRQOL) in pediatric patients with T1D. In a cross-sectional study we identified eligible 332 patients with T1D aged 8–18 years, of whom 248 (75%) together with their parents responded to the PedsQL Generic and Diabetes Modules. Compared to 143 patients without thyroid autoantibodies, 40 patients with a thyroxine-treated AITD scored lower in the overall generic HRQOL (P = 0.014), as well as in the overall diabetes-specific HRQOL (P = 0.013). After adjustment for age, gender, duration of diabetes, type of diabetes treatment, and diabetes control, this association remained statistically significant for the generic HRQOL (P = 0.023). Celiac disease was not associated with a change in the generic or diabetes-specific HRQOL (P = 0.07 and P = 0.63, resp.). Parental scores showed no association with AITD or celiac disease, except a marginally significant decrease in the overall generic HRQOL (P = 0.039) in the T1D + AITD compared to T1D group. Our study indicates that, in pediatric patients with T1D, concomitant thyroxine-treated AITD is associated with lower quality of life. Hindawi Publishing Corporation 2015 2015-05-18 /pmc/articles/PMC4451782/ /pubmed/26089877 http://dx.doi.org/10.1155/2015/185859 Text en Copyright © 2015 Alena Spirkova et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Spirkova, Alena Dusatkova, Petra Peckova, Monika Kolouskova, Stanislava Snajderova, Marta Obermannova, Barbora Stechova, Katerina Hrachovinova, Tamara Mares, Jiri Cinek, Ondrej Lebl, Jan Sumnik, Zdenek Pruhova, Stepanka Treated Autoimmune Thyroid Disease Is Associated with a Decreased Quality of Life among Young Persons with Type 1 Diabetes |
title | Treated Autoimmune Thyroid Disease Is Associated with a Decreased Quality of Life among Young Persons with Type 1 Diabetes |
title_full | Treated Autoimmune Thyroid Disease Is Associated with a Decreased Quality of Life among Young Persons with Type 1 Diabetes |
title_fullStr | Treated Autoimmune Thyroid Disease Is Associated with a Decreased Quality of Life among Young Persons with Type 1 Diabetes |
title_full_unstemmed | Treated Autoimmune Thyroid Disease Is Associated with a Decreased Quality of Life among Young Persons with Type 1 Diabetes |
title_short | Treated Autoimmune Thyroid Disease Is Associated with a Decreased Quality of Life among Young Persons with Type 1 Diabetes |
title_sort | treated autoimmune thyroid disease is associated with a decreased quality of life among young persons with type 1 diabetes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451782/ https://www.ncbi.nlm.nih.gov/pubmed/26089877 http://dx.doi.org/10.1155/2015/185859 |
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