Two-stage therapeutic utility of ectopically formed bone tissue in skeletal muscle induced by adeno-associated virus containing bone morphogenetic protein-4 gene

BACKGROUND: The major disadvantage of using a stem cell-based bone morphogenetic protein-4 (BMP4) gene therapy for skull defect is the overgrowth of generated bone tissue in situ. In the present study, to overcome bony overgrowth of stem cell based-gene therapy, a new strategy of two-stage bone tiss...

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Detalles Bibliográficos
Autores principales: Tian, Ke, Qi, Min, Wang, Limin, Li, Zhifu, Xu, Jianzhong, Li, Yi, Liu, Guanlei, Wang, Bing, Huard, Johnny, Li, Guangheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451875/
https://www.ncbi.nlm.nih.gov/pubmed/26024920
http://dx.doi.org/10.1186/s13018-015-0229-1

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