Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus

To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previo...

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Autores principales: van der Linden, J.W.M., Arendrup, M.C., Warris, A., Lagrou, K., Pelloux, H., Hauser, P.M., Chryssanthou, E., Mellado, E., Kidd, S.E., Tortorano, A.M., Dannaoui, E., Gaustad, P., Baddley, J.W., Uekötter, A., Lass-Flörl, C., Klimko, N., Moore, C.B., Denning, D.W., Pasqualotto, A.C., Kibbler, C., Arikan-Akdagli, S., Andes, D., Meletiadis, J., Naumiuk, L., Nucci, M., Melchers, W.J.G., Verweij, P.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2015
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451897/
https://www.ncbi.nlm.nih.gov/pubmed/25988348
http://dx.doi.org/10.3201/eid2106.140717
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author van der Linden, J.W.M.
Arendrup, M.C.
Warris, A.
Lagrou, K.
Pelloux, H.
Hauser, P.M.
Chryssanthou, E.
Mellado, E.
Kidd, S.E.
Tortorano, A.M.
Dannaoui, E.
Gaustad, P.
Baddley, J.W.
Uekötter, A.
Lass-Flörl, C.
Klimko, N.
Moore, C.B.
Denning, D.W.
Pasqualotto, A.C.
Kibbler, C.
Arikan-Akdagli, S.
Andes, D.
Meletiadis, J.
Naumiuk, L.
Nucci, M.
Melchers, W.J.G.
Verweij, P.E.
author_facet van der Linden, J.W.M.
Arendrup, M.C.
Warris, A.
Lagrou, K.
Pelloux, H.
Hauser, P.M.
Chryssanthou, E.
Mellado, E.
Kidd, S.E.
Tortorano, A.M.
Dannaoui, E.
Gaustad, P.
Baddley, J.W.
Uekötter, A.
Lass-Flörl, C.
Klimko, N.
Moore, C.B.
Denning, D.W.
Pasqualotto, A.C.
Kibbler, C.
Arikan-Akdagli, S.
Andes, D.
Meletiadis, J.
Naumiuk, L.
Nucci, M.
Melchers, W.J.G.
Verweij, P.E.
author_sort van der Linden, J.W.M.
collection PubMed
description To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.
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spelling pubmed-44518972015-06-09 Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus van der Linden, J.W.M. Arendrup, M.C. Warris, A. Lagrou, K. Pelloux, H. Hauser, P.M. Chryssanthou, E. Mellado, E. Kidd, S.E. Tortorano, A.M. Dannaoui, E. Gaustad, P. Baddley, J.W. Uekötter, A. Lass-Flörl, C. Klimko, N. Moore, C.B. Denning, D.W. Pasqualotto, A.C. Kibbler, C. Arikan-Akdagli, S. Andes, D. Meletiadis, J. Naumiuk, L. Nucci, M. Melchers, W.J.G. Verweij, P.E. Emerg Infect Dis Dispatch To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles. Centers for Disease Control and Prevention 2015-06 /pmc/articles/PMC4451897/ /pubmed/25988348 http://dx.doi.org/10.3201/eid2106.140717 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
van der Linden, J.W.M.
Arendrup, M.C.
Warris, A.
Lagrou, K.
Pelloux, H.
Hauser, P.M.
Chryssanthou, E.
Mellado, E.
Kidd, S.E.
Tortorano, A.M.
Dannaoui, E.
Gaustad, P.
Baddley, J.W.
Uekötter, A.
Lass-Flörl, C.
Klimko, N.
Moore, C.B.
Denning, D.W.
Pasqualotto, A.C.
Kibbler, C.
Arikan-Akdagli, S.
Andes, D.
Meletiadis, J.
Naumiuk, L.
Nucci, M.
Melchers, W.J.G.
Verweij, P.E.
Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus
title Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus
title_full Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus
title_fullStr Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus
title_full_unstemmed Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus
title_short Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus
title_sort prospective multicenter international surveillance of azole resistance in aspergillus fumigatus
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451897/
https://www.ncbi.nlm.nih.gov/pubmed/25988348
http://dx.doi.org/10.3201/eid2106.140717
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