Matrix stiffness drives Epithelial-Mesenchymal Transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway

Matrix stiffness potently regulates cellular behavior in various biological contexts. In breast tumours, the presence of dense clusters of collagen fibrils indicates increased matrix stiffness and correlates with poor survival. It is unclear how mechanical inputs are transduced into transcriptional...

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Detalles Bibliográficos
Autores principales: Wei, Spencer C., Fattet, Laurent, Tsai, Jeff H., Guo, Yurong, Pai, Vincent H., Majeski, Hannah E., Chen, Albert C., Sah, Robert L., Taylor, Susan S., Engler, Adam J., Yang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452027/
https://www.ncbi.nlm.nih.gov/pubmed/25893917
http://dx.doi.org/10.1038/ncb3157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452027/
https://www.ncbi.nlm.nih.gov/pubmed/25893917
http://dx.doi.org/10.1038/ncb3157

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