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Intelligent system design for bionanorobots in drug delivery
A nanorobot is defined as any smart structure which is capable of actuation, sensing, manipulation, intelligence, and swarm behavior at the nanoscale. In this study, we designed an intelligent system using fuzzy logic for diagnosis and treatment of tumors inside the human body using bionanorobots. W...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452041/ https://www.ncbi.nlm.nih.gov/pubmed/26069507 http://dx.doi.org/10.1007/s12645-013-0044-5 |
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author | Fletcher, Mark Biglarbegian, Mohammad Neethirajan, Suresh |
author_facet | Fletcher, Mark Biglarbegian, Mohammad Neethirajan, Suresh |
author_sort | Fletcher, Mark |
collection | PubMed |
description | A nanorobot is defined as any smart structure which is capable of actuation, sensing, manipulation, intelligence, and swarm behavior at the nanoscale. In this study, we designed an intelligent system using fuzzy logic for diagnosis and treatment of tumors inside the human body using bionanorobots. We utilize fuzzy logic and a combination of thermal, magnetic, optical, and chemical nanosensors to interpret the uncertainty associated with the sensory information. Two different fuzzy logic structures, for diagnosis (Mamdani structure) and for cure (Takagi–Sugeno structure), were developed to efficiently identify the tumors and treat them through delivery of effective dosages of a drug. Validation of the designed system with simulated conditions proved that the drug delivery of bionanorobots was robust to reasonable noise that may occur in the bionanorobot sensors during navigation, diagnosis, and curing of the cancer cells. Bionanorobots represent a great hope for successful cancer therapy in the near future. |
format | Online Article Text |
id | pubmed-4452041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-44520412015-06-09 Intelligent system design for bionanorobots in drug delivery Fletcher, Mark Biglarbegian, Mohammad Neethirajan, Suresh Cancer Nanotechnol Original Paper A nanorobot is defined as any smart structure which is capable of actuation, sensing, manipulation, intelligence, and swarm behavior at the nanoscale. In this study, we designed an intelligent system using fuzzy logic for diagnosis and treatment of tumors inside the human body using bionanorobots. We utilize fuzzy logic and a combination of thermal, magnetic, optical, and chemical nanosensors to interpret the uncertainty associated with the sensory information. Two different fuzzy logic structures, for diagnosis (Mamdani structure) and for cure (Takagi–Sugeno structure), were developed to efficiently identify the tumors and treat them through delivery of effective dosages of a drug. Validation of the designed system with simulated conditions proved that the drug delivery of bionanorobots was robust to reasonable noise that may occur in the bionanorobot sensors during navigation, diagnosis, and curing of the cancer cells. Bionanorobots represent a great hope for successful cancer therapy in the near future. Springer Vienna 2013-07-14 2013 /pmc/articles/PMC4452041/ /pubmed/26069507 http://dx.doi.org/10.1007/s12645-013-0044-5 Text en © Springer-Verlag Wien 2013 |
spellingShingle | Original Paper Fletcher, Mark Biglarbegian, Mohammad Neethirajan, Suresh Intelligent system design for bionanorobots in drug delivery |
title | Intelligent system design for bionanorobots in drug delivery |
title_full | Intelligent system design for bionanorobots in drug delivery |
title_fullStr | Intelligent system design for bionanorobots in drug delivery |
title_full_unstemmed | Intelligent system design for bionanorobots in drug delivery |
title_short | Intelligent system design for bionanorobots in drug delivery |
title_sort | intelligent system design for bionanorobots in drug delivery |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452041/ https://www.ncbi.nlm.nih.gov/pubmed/26069507 http://dx.doi.org/10.1007/s12645-013-0044-5 |
work_keys_str_mv | AT fletchermark intelligentsystemdesignforbionanorobotsindrugdelivery AT biglarbegianmohammad intelligentsystemdesignforbionanorobotsindrugdelivery AT neethirajansuresh intelligentsystemdesignforbionanorobotsindrugdelivery |