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Intelligent system design for bionanorobots in drug delivery

A nanorobot is defined as any smart structure which is capable of actuation, sensing, manipulation, intelligence, and swarm behavior at the nanoscale. In this study, we designed an intelligent system using fuzzy logic for diagnosis and treatment of tumors inside the human body using bionanorobots. W...

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Detalles Bibliográficos
Autores principales: Fletcher, Mark, Biglarbegian, Mohammad, Neethirajan, Suresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452041/
https://www.ncbi.nlm.nih.gov/pubmed/26069507
http://dx.doi.org/10.1007/s12645-013-0044-5
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author Fletcher, Mark
Biglarbegian, Mohammad
Neethirajan, Suresh
author_facet Fletcher, Mark
Biglarbegian, Mohammad
Neethirajan, Suresh
author_sort Fletcher, Mark
collection PubMed
description A nanorobot is defined as any smart structure which is capable of actuation, sensing, manipulation, intelligence, and swarm behavior at the nanoscale. In this study, we designed an intelligent system using fuzzy logic for diagnosis and treatment of tumors inside the human body using bionanorobots. We utilize fuzzy logic and a combination of thermal, magnetic, optical, and chemical nanosensors to interpret the uncertainty associated with the sensory information. Two different fuzzy logic structures, for diagnosis (Mamdani structure) and for cure (Takagi–Sugeno structure), were developed to efficiently identify the tumors and treat them through delivery of effective dosages of a drug. Validation of the designed system with simulated conditions proved that the drug delivery of bionanorobots was robust to reasonable noise that may occur in the bionanorobot sensors during navigation, diagnosis, and curing of the cancer cells. Bionanorobots represent a great hope for successful cancer therapy in the near future.
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spelling pubmed-44520412015-06-09 Intelligent system design for bionanorobots in drug delivery Fletcher, Mark Biglarbegian, Mohammad Neethirajan, Suresh Cancer Nanotechnol Original Paper A nanorobot is defined as any smart structure which is capable of actuation, sensing, manipulation, intelligence, and swarm behavior at the nanoscale. In this study, we designed an intelligent system using fuzzy logic for diagnosis and treatment of tumors inside the human body using bionanorobots. We utilize fuzzy logic and a combination of thermal, magnetic, optical, and chemical nanosensors to interpret the uncertainty associated with the sensory information. Two different fuzzy logic structures, for diagnosis (Mamdani structure) and for cure (Takagi–Sugeno structure), were developed to efficiently identify the tumors and treat them through delivery of effective dosages of a drug. Validation of the designed system with simulated conditions proved that the drug delivery of bionanorobots was robust to reasonable noise that may occur in the bionanorobot sensors during navigation, diagnosis, and curing of the cancer cells. Bionanorobots represent a great hope for successful cancer therapy in the near future. Springer Vienna 2013-07-14 2013 /pmc/articles/PMC4452041/ /pubmed/26069507 http://dx.doi.org/10.1007/s12645-013-0044-5 Text en © Springer-Verlag Wien 2013
spellingShingle Original Paper
Fletcher, Mark
Biglarbegian, Mohammad
Neethirajan, Suresh
Intelligent system design for bionanorobots in drug delivery
title Intelligent system design for bionanorobots in drug delivery
title_full Intelligent system design for bionanorobots in drug delivery
title_fullStr Intelligent system design for bionanorobots in drug delivery
title_full_unstemmed Intelligent system design for bionanorobots in drug delivery
title_short Intelligent system design for bionanorobots in drug delivery
title_sort intelligent system design for bionanorobots in drug delivery
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452041/
https://www.ncbi.nlm.nih.gov/pubmed/26069507
http://dx.doi.org/10.1007/s12645-013-0044-5
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