Selective vulnerability of motoneuron and perturbed mitochondrial calcium homeostasis in amyotrophic lateral sclerosis: implications for motoneurons specific calcium dysregulation

Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder characterized by the selective degeneration of defined subgroups of motoneuron in the brainstem, spinal cord and motor cortex with signature hallmarks of mitochondrial Ca(2+) overload, free radical damage, excitotoxicity and...

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Detalles Bibliográficos
Autor principal: Jaiswal, Manoj Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452055/
https://www.ncbi.nlm.nih.gov/pubmed/26056593
http://dx.doi.org/10.1186/2052-8426-2-26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452055/
https://www.ncbi.nlm.nih.gov/pubmed/26056593
http://dx.doi.org/10.1186/2052-8426-2-26

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