Neural stem cells: ready for therapeutic applications?

Neural stem cells (NSCs) offer a unique and powerful tool for basic research and regenerative medicine. However, the challenges that scientists face in the comprehension of the biology and physiological function of these cells are still many. Deciphering NSCs fundamental biological aspects represent...

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Detalles Bibliográficos
Autores principales: Casarosa, Simona, Bozzi, Yuri, Conti, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452059/
https://www.ncbi.nlm.nih.gov/pubmed/26056597
http://dx.doi.org/10.1186/2052-8426-2-31
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author Casarosa, Simona
Bozzi, Yuri
Conti, Luciano
author_facet Casarosa, Simona
Bozzi, Yuri
Conti, Luciano
author_sort Casarosa, Simona
collection PubMed
description Neural stem cells (NSCs) offer a unique and powerful tool for basic research and regenerative medicine. However, the challenges that scientists face in the comprehension of the biology and physiological function of these cells are still many. Deciphering NSCs fundamental biological aspects represents indeed a crucial step to control NSCs fate and functional integration following transplantation, and is essential for a safe and appropriate use of NSCs in injury/disease conditions. In this review, we focus on the biological properties of NSCs and discuss how these cells may be exploited to provide effective therapies for neurological disorders. We also review and discuss ongoing NSC-based clinical trials for these diseases.
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spelling pubmed-44520592015-06-09 Neural stem cells: ready for therapeutic applications? Casarosa, Simona Bozzi, Yuri Conti, Luciano Mol Cell Ther Review Neural stem cells (NSCs) offer a unique and powerful tool for basic research and regenerative medicine. However, the challenges that scientists face in the comprehension of the biology and physiological function of these cells are still many. Deciphering NSCs fundamental biological aspects represents indeed a crucial step to control NSCs fate and functional integration following transplantation, and is essential for a safe and appropriate use of NSCs in injury/disease conditions. In this review, we focus on the biological properties of NSCs and discuss how these cells may be exploited to provide effective therapies for neurological disorders. We also review and discuss ongoing NSC-based clinical trials for these diseases. BioMed Central 2014-10-15 /pmc/articles/PMC4452059/ /pubmed/26056597 http://dx.doi.org/10.1186/2052-8426-2-31 Text en © Casarosa et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Casarosa, Simona
Bozzi, Yuri
Conti, Luciano
Neural stem cells: ready for therapeutic applications?
title Neural stem cells: ready for therapeutic applications?
title_full Neural stem cells: ready for therapeutic applications?
title_fullStr Neural stem cells: ready for therapeutic applications?
title_full_unstemmed Neural stem cells: ready for therapeutic applications?
title_short Neural stem cells: ready for therapeutic applications?
title_sort neural stem cells: ready for therapeutic applications?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452059/
https://www.ncbi.nlm.nih.gov/pubmed/26056597
http://dx.doi.org/10.1186/2052-8426-2-31
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