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Suppression of silent information regulator 1 activity in noncancerous tissues of hepatocellular carcinoma: Possible association with non-B non-C hepatitis pathogenesis

Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylase. In mice, mSirt1 deficiency causes the onset of fatty liver via regulation of the hepatic nutrient metabolism pathway. In this study, we demonstrate SIRT1 expression, activity and NAD...

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Detalles Bibliográficos
Autores principales:	Konishi, Hideyuki, Shirabe, Ken, Nakagawara, Hidekazu, Harimoto, Norifumi, Yamashita, Yo-Ichi, Ikegami, Toru, Yoshizumi, Tomoharu, Soejima, Yuji, Oda, Yoshinao, Maehara, Yoshihiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452154/ https://www.ncbi.nlm.nih.gov/pubmed/25736100 http://dx.doi.org/10.1111/cas.12653

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