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Therapeutic advances in BIG3-PHB2 inhibition targeting the crosstalk between estrogen and growth factors in breast cancer

Our previous studies demonstrated that specific inhibition of the BIG3-PHB2 complex, which is a critical modulator in estrogen (E2) signaling, using ERAP, a dominant negative peptide inhibitor, leads to suppression of E2-dependent estrogen receptor (ER) alpha activation through the reactivation of t...

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Detalles Bibliográficos
Autores principales:	Yoshimaru, Tetsuro, Komatsu, Masato, Miyoshi, Yasuo, Honda, Junko, Sasa, Mitsunori, Katagiri, Toyomasa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452155/ https://www.ncbi.nlm.nih.gov/pubmed/25736224 http://dx.doi.org/10.1111/cas.12654

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