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Activation of AMP-activated protein kinase by retinoic acid sensitizes hepatocellular carcinoma cells to apoptosis induced by sorafenib

To improve the outcome of cancer chemotherapy, strategies to enhance the efficacy of anticancer drugs are required. Sorafenib is the only drug to prolong overall survival of the patients with hepatocellular carcinoma (HCC), however, the outcome is still not satisfactory. Retinoids, vitamin A derivat...

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Detalles Bibliográficos
Autores principales: Ishijima, Naoki, Kanki, Keita, Shimizu, Hiroki, Shiota, Goshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452157/
https://www.ncbi.nlm.nih.gov/pubmed/25683251
http://dx.doi.org/10.1111/cas.12633