Cargando…

Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations

PURPOSE: In the present study we investigated the root-cause of an interference signal (100–200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products. METHODS:...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weinbuch, Daniel, Cheung, Jason K., Ketelaars, Jurgen, Filipe, Vasco, Hawe, Andrea, den Engelsman, John, Jiskoot, Wim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452213/ https://www.ncbi.nlm.nih.gov/pubmed/25630820 http://dx.doi.org/10.1007/s11095-015-1634-1

Ejemplares similares

Fluorescent Molecular Rotors as Dyes to Characterize Polysorbate-Containing IgG Formulations
por: Hawe, Andrea, et al.
Publicado: (2009)

Critical Evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the Measurement of Nanoparticles and Protein Aggregates
por: Filipe, Vasco, et al.
Publicado: (2010)

Taylor Dispersion Analysis Compared to Dynamic Light Scattering for the Size Analysis of Therapeutic Peptides and Proteins and Their Aggregates
por: Hawe, Andrea, et al.
Publicado: (2011)

Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity
por: Scott, Daniel, et al.
Publicado: (2011)

Amorphous Nanoparticulate Formulation of Sirolimus and Its Tablets
por: Shen, Yudong, et al.
Publicado: (2018)

Fluorescence Single Particle Tracking for the Characterization of Submicron Protein Aggregates in Biological Fluids and Complex Formulations
por: Filipe, Vasco, et al.
Publicado: (2011)

Towards Heat-stable Oxytocin Formulations: Analysis of Degradation Kinetics and Identification of Degradation Products
por: Hawe, Andrea, et al.
Publicado: (2009)

Development of Nanoparticulate Formulations with Biomedical Applications Related to Cancer
por: Soica, Codruta Marinela
Publicado: (2019)

Composites of Polymer Hydrogels and Nanoparticulate Systems for Biomedical and Pharmaceutical Applications
por: Zhao, Fuli, et al.
Publicado: (2015)

Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development
por: den Engelsman, John, et al.
Publicado: (2010)

Impurity scattering in metallic alloys
por: Galsin, Joginder Singh
Publicado: (2002)

Recent trends in the impurity profile of pharmaceuticals
por: Pilaniya, Kavita, et al.
Publicado: (2010)

Extrinsic Fluorescent Dyes as Tools for Protein Characterization
por: Hawe, Andrea, et al.
Publicado: (2008)

Organic Salts of Pharmaceutical Impurity p-Aminophenol
por: Khandavilli, U. B. Rao, et al.
Publicado: (2020)

Development and Validation of a Stability-Indicating RP-HPLC Method for the Estimation of Drotaverine Impurities in API and Pharmaceutical Formulation
por: Thummala, Veera Raghava Raju, et al.
Publicado: (2014)

Formulation and evaluation of butenafine loaded PLGA-nanoparticulate laden chitosan nano gel
por: Alshehri, Sultan, et al.
Publicado: (2021)

A spectrofluorometric analysis to evaluate transcutaneous biodistribution of fluorescent nanoparticulate gel formulations
por: Cappellozza, Enrica, et al.
Publicado: (2022)

Determination of Chiral Impurity of Naproxen in Different Pharmaceutical Formulations Using Polysaccharide-Based Stationary Phases in Reversed-Phased Mode
por: Papp, Lajos-Attila, et al.
Publicado: (2022)

High potency of lipid conjugated TLR7 agonist requires nanoparticulate or liposomal formulation
por: Gadd, Adam J.R., et al.
Publicado: (2018)

Nanoparticulate Tubular Immunostimulating Complexes: Novel Formulation of Effective Adjuvants and Antigen Delivery Systems
por: Sanina, Nina, et al.
Publicado: (2017)

Modeling and Simulation of Process Technology for Nanoparticulate Drug Formulations—A Particle Technology Perspective
por: Uhlemann, Jens, et al.
Publicado: (2020)

Formulation, Optimization and Evaluation of Luteolin-Loaded Topical Nanoparticulate Delivery System for the Skin Cancer
por: Kazmi, Imran, et al.
Publicado: (2021)

Formulation and Evaluation of PLGA Nanoparticulate-Based Microneedle System for Potential Treatment of Neurological Diseases
por: Li, Baohua, et al.
Publicado: (2023)

Many-impurity scattering on the surface of a topological insulator
por: Hernando, José Luis, et al.
Publicado: (2021)

Molecularly Imprinted Polymers for Pharmaceutical Impurities: Design and Synthesis Methods
por: Hasanah, Aliya Nur, et al.
Publicado: (2023)

Photodynamic therapy with conventional and PEGylated liposomal formulations of mTHPC (temoporfin): comparison of treatment efficacy and distribution characteristics in vivo
por: Reshetov, Vadzim, et al.
Publicado: (2013)

Tailoring Midazolam-Loaded Chitosan Nanoparticulate Formulation for Enhanced Brain Delivery via Intranasal Route
por: Shrestha, Nikesh, et al.
Publicado: (2020)

Quality by Design (QbD) Approach for a Nanoparticulate Imiquimod Formulation as an Investigational Medicinal Product
por: Pielenhofer, Jonas, et al.
Publicado: (2023)

Detection and Characterization of Subvisible Aggregates of Monoclonal IgG in Serum
por: Filipe, Vasco, et al.
Publicado: (2012)

Development and Validation of a Stability-Indicating RP-HPLC Method for the Determination of Process-Related Impurities and Degradation Products of Rabeprazole Sodium in Pharmaceutical Formulation
por: Kumar, Navneet, et al.
Publicado: (2013)

Nanoparticulate systems for polynucleotide delivery
por: Basarkar, Ashwin, et al.
Publicado: (2007)

Mercury Reduction by Nanoparticulate Vivianite
por: Etique, Marjorie, et al.
Publicado: (2021)

Impact of Pharmaceutical Impurities in Ecstasy Tablets: Gas Chromatography-Mass Spectrometry Study
por: Jalali, Amir, et al.
Publicado: (2016)

Spectrofluorimetric determination of selected genotoxic impurities in pharmaceutical raw materials and final products
por: Shallan, Aliaa I., et al.
Publicado: (2022)

Formulation, Delivery and Stability of Bone Morphogenetic Proteins for Effective Bone Regeneration
por: El Bialy, Inas, et al.
Publicado: (2017)

The Molecular Chaperone α-Crystallin as an Excipient in an Insulin Formulation
por: Rasmussen, Tue, et al.
Publicado: (2010)

Effects of Impurities from Sugar Excipient on Filtrate Flux during Ultrafiltration and Diafiltration Process
por: Lee, Jieun, et al.
Publicado: (2021)

Photoproduction of iodine with nanoparticulate semiconductors and insulators
por: Karunakaran, Chockalingam, et al.
Publicado: (2011)

Nanoparticulate carriers for the treatment of coronary restenosis
por: Brito, Luis, et al.
Publicado: (2007)

Anticancer nanoparticulate polymer‐drug conjugate
por: Feng, Quanyou, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_cci34t2kvhfiq64ik6j3q69vjc