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Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites
In eukaryotic cells, proteasomes perform crucial roles in many cellular pathways by degrading proteins to enforce quality control and regulate many cellular processes such as cell cycle progression, signal transduction, cell death, immune responses, metabolism, protein-quality control, and developme...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452248/ https://www.ncbi.nlm.nih.gov/pubmed/26090380 http://dx.doi.org/10.1155/2015/141526 |
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author | Muñoz, Christian San Francisco, Juan Gutiérrez, Bessy González, Jorge |
author_facet | Muñoz, Christian San Francisco, Juan Gutiérrez, Bessy González, Jorge |
author_sort | Muñoz, Christian |
collection | PubMed |
description | In eukaryotic cells, proteasomes perform crucial roles in many cellular pathways by degrading proteins to enforce quality control and regulate many cellular processes such as cell cycle progression, signal transduction, cell death, immune responses, metabolism, protein-quality control, and development. The catalytic heart of these complexes, the 20S proteasome, is highly conserved in bacteria, yeast, and humans. However, until a few years ago, the role of proteasomes in parasite biology was completely unknown. Here, we summarize findings about the role of proteasomes in protozoan parasites biology and virulence. Several reports have confirmed the role of proteasomes in parasite biological processes such as cell differentiation, cell cycle, proliferation, and encystation. Proliferation and cell differentiation are key steps in host colonization. Considering the importance of proteasomes in both processes in many different parasites such as Trypanosoma, Leishmania, Toxoplasma, and Entamoeba, parasite proteasomes might serve as virulence factors. Several pieces of evidence strongly suggest that the ubiquitin-proteasome pathway is also a viable parasitic therapeutic target. Research in recent years has shown that the proteasome is a valid drug target for sleeping sickness and malaria. Then, proteasomes are a key organelle in parasite biology and virulence and appear to be an attractive new chemotherapeutic target. |
format | Online Article Text |
id | pubmed-4452248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44522482015-06-18 Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites Muñoz, Christian San Francisco, Juan Gutiérrez, Bessy González, Jorge Biomed Res Int Review Article In eukaryotic cells, proteasomes perform crucial roles in many cellular pathways by degrading proteins to enforce quality control and regulate many cellular processes such as cell cycle progression, signal transduction, cell death, immune responses, metabolism, protein-quality control, and development. The catalytic heart of these complexes, the 20S proteasome, is highly conserved in bacteria, yeast, and humans. However, until a few years ago, the role of proteasomes in parasite biology was completely unknown. Here, we summarize findings about the role of proteasomes in protozoan parasites biology and virulence. Several reports have confirmed the role of proteasomes in parasite biological processes such as cell differentiation, cell cycle, proliferation, and encystation. Proliferation and cell differentiation are key steps in host colonization. Considering the importance of proteasomes in both processes in many different parasites such as Trypanosoma, Leishmania, Toxoplasma, and Entamoeba, parasite proteasomes might serve as virulence factors. Several pieces of evidence strongly suggest that the ubiquitin-proteasome pathway is also a viable parasitic therapeutic target. Research in recent years has shown that the proteasome is a valid drug target for sleeping sickness and malaria. Then, proteasomes are a key organelle in parasite biology and virulence and appear to be an attractive new chemotherapeutic target. Hindawi Publishing Corporation 2015 2015-05-19 /pmc/articles/PMC4452248/ /pubmed/26090380 http://dx.doi.org/10.1155/2015/141526 Text en Copyright © 2015 Christian Muñoz et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Muñoz, Christian San Francisco, Juan Gutiérrez, Bessy González, Jorge Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites |
title | Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites |
title_full | Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites |
title_fullStr | Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites |
title_full_unstemmed | Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites |
title_short | Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites |
title_sort | role of the ubiquitin-proteasome systems in the biology and virulence of protozoan parasites |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452248/ https://www.ncbi.nlm.nih.gov/pubmed/26090380 http://dx.doi.org/10.1155/2015/141526 |
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