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Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis
Objective. To evaluate whether serum titers of second-generation anticyclic citrullinated peptide antibodies (anti-CCP2) are associated with the severity and extent of interstitial lung disease in rheumatoid arthritis (RA-ILD). Methods. In across-sectional study, 39 RA-ILD patients confirmed by high...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452340/ https://www.ncbi.nlm.nih.gov/pubmed/26090479 http://dx.doi.org/10.1155/2015/151626 |
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author | Rocha-Muñoz, Alberto Daniel Ponce-Guarneros, Manuel Gamez-Nava, Jorge Ivan Olivas-Flores, Eva Maria Mejía, Mayra Juárez-Contreras, Pablo Martínez-García, Erika Aurora Corona-Sánchez, Esther Guadalupe Rodríguez-Hernández, Tania Marlen Vázquez-del Mercado, Mónica Salazar-Páramo, Mario Nava-Zavala, Arnulfo Hernan Cardona-Muñoz, Ernesto German Celis, Alfredo González-Lopez, Laura |
author_facet | Rocha-Muñoz, Alberto Daniel Ponce-Guarneros, Manuel Gamez-Nava, Jorge Ivan Olivas-Flores, Eva Maria Mejía, Mayra Juárez-Contreras, Pablo Martínez-García, Erika Aurora Corona-Sánchez, Esther Guadalupe Rodríguez-Hernández, Tania Marlen Vázquez-del Mercado, Mónica Salazar-Páramo, Mario Nava-Zavala, Arnulfo Hernan Cardona-Muñoz, Ernesto German Celis, Alfredo González-Lopez, Laura |
author_sort | Rocha-Muñoz, Alberto Daniel |
collection | PubMed |
description | Objective. To evaluate whether serum titers of second-generation anticyclic citrullinated peptide antibodies (anti-CCP2) are associated with the severity and extent of interstitial lung disease in rheumatoid arthritis (RA-ILD). Methods. In across-sectional study, 39 RA-ILD patients confirmed by high-resolution computed tomography (HRCT) were compared with 42 RA without lung involvement (RA only). Characteristics related to RA-ILD were assessed in all of the patients and serum anti-CCP2 titers quantified. Results. Higher anti-CCP2 titers were found in RA-ILD compared with RA only (medians 77.9 versus 30.2 U/mL, P < 0.001). In the logistic regression analysis after adjustment for age, disease duration (DD), smoke exposure, disease activity, functioning, erythrocyte sedimentation rate, and methotrexate (MTX) treatment duration, the characteristics associated with RA-ILD were higher anti-CCP2 titers (P = 0.003) and + RF (P = 0.002). In multivariate linear regression, the variables associated with severity of ground-glass score were anti-CCP2 titers (P = 0.02) and with fibrosis score DD (P = 0.01), anti-CCP2 titers (P < 0.001), and MTX treatment duration (P < 0.001). Conclusions. Anti-CCP2 antibodies are markers of severity and extent of RA-ILD in HRCT. Further longitudinal studies are required to identify if higher anti-CCP2 titers are associated with worst prognosis in RA-ILD. |
format | Online Article Text |
id | pubmed-4452340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44523402015-06-18 Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis Rocha-Muñoz, Alberto Daniel Ponce-Guarneros, Manuel Gamez-Nava, Jorge Ivan Olivas-Flores, Eva Maria Mejía, Mayra Juárez-Contreras, Pablo Martínez-García, Erika Aurora Corona-Sánchez, Esther Guadalupe Rodríguez-Hernández, Tania Marlen Vázquez-del Mercado, Mónica Salazar-Páramo, Mario Nava-Zavala, Arnulfo Hernan Cardona-Muñoz, Ernesto German Celis, Alfredo González-Lopez, Laura J Immunol Res Research Article Objective. To evaluate whether serum titers of second-generation anticyclic citrullinated peptide antibodies (anti-CCP2) are associated with the severity and extent of interstitial lung disease in rheumatoid arthritis (RA-ILD). Methods. In across-sectional study, 39 RA-ILD patients confirmed by high-resolution computed tomography (HRCT) were compared with 42 RA without lung involvement (RA only). Characteristics related to RA-ILD were assessed in all of the patients and serum anti-CCP2 titers quantified. Results. Higher anti-CCP2 titers were found in RA-ILD compared with RA only (medians 77.9 versus 30.2 U/mL, P < 0.001). In the logistic regression analysis after adjustment for age, disease duration (DD), smoke exposure, disease activity, functioning, erythrocyte sedimentation rate, and methotrexate (MTX) treatment duration, the characteristics associated with RA-ILD were higher anti-CCP2 titers (P = 0.003) and + RF (P = 0.002). In multivariate linear regression, the variables associated with severity of ground-glass score were anti-CCP2 titers (P = 0.02) and with fibrosis score DD (P = 0.01), anti-CCP2 titers (P < 0.001), and MTX treatment duration (P < 0.001). Conclusions. Anti-CCP2 antibodies are markers of severity and extent of RA-ILD in HRCT. Further longitudinal studies are required to identify if higher anti-CCP2 titers are associated with worst prognosis in RA-ILD. Hindawi Publishing Corporation 2015 2015-05-19 /pmc/articles/PMC4452340/ /pubmed/26090479 http://dx.doi.org/10.1155/2015/151626 Text en Copyright © 2015 Alberto Daniel Rocha-Muñoz et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Rocha-Muñoz, Alberto Daniel Ponce-Guarneros, Manuel Gamez-Nava, Jorge Ivan Olivas-Flores, Eva Maria Mejía, Mayra Juárez-Contreras, Pablo Martínez-García, Erika Aurora Corona-Sánchez, Esther Guadalupe Rodríguez-Hernández, Tania Marlen Vázquez-del Mercado, Mónica Salazar-Páramo, Mario Nava-Zavala, Arnulfo Hernan Cardona-Muñoz, Ernesto German Celis, Alfredo González-Lopez, Laura Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis |
title | Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis |
title_full | Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis |
title_fullStr | Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis |
title_full_unstemmed | Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis |
title_short | Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis |
title_sort | anti-cyclic citrullinated peptide antibodies and severity of interstitial lung disease in women with rheumatoid arthritis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452340/ https://www.ncbi.nlm.nih.gov/pubmed/26090479 http://dx.doi.org/10.1155/2015/151626 |
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