Localized CCR2 Activation in the Bone Marrow Niche Mobilizes Monocytes by Desensitizing CXCR4

Inflammatory (classical) monocytes residing in the bone marrow must enter the bloodstream in order to combat microbe infection. These monocytes express high levels of CCR2, a chemokine receptor whose activation is required for them to exit the bone marrow. How CCR2 is locally activated in the bone m...

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Detalles Bibliográficos
Autores principales: Jung, Hosung, Mithal, Divakar S., Park, Jeong Eun, Miller, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452517/
https://www.ncbi.nlm.nih.gov/pubmed/26029924
http://dx.doi.org/10.1371/journal.pone.0128387

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